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Merck
CN

78666

Taxifolin

analytical standard

Synonym(s):

(2R,3R)-3,3′,4′,5,7-Pentahydroxyflavanone, (2R,3R)-Dihydroquercetin

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About This Item

Empirical Formula (Hill Notation):
C15H12O7
CAS Number:
480-18-2
Molecular Weight:
304.25
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
329768169
EC Number:
207-543-4
Beilstein/REAXYS Number:
5299277
MDL number:
MFCD00006845

Key Documents

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Product Name

Taxifolin, analytical standard

InChI key

CXQWRCVTCMQVQX-LSDHHAIUSA-N

InChI

1S/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m0/s1

SMILES string

O[C@@H]1[C@H](Oc2cc(O)cc(O)c2C1=O)c3ccc(O)c(O)c3

grade

analytical standard

assay

≥85% (HPLC)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

Quality Level

100

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Taxifolin can be used as a reference standard for the determination of taxifolin in plasma of rabbit using high performance liquid chromatography technique(HPLC).

General description

Taxifolin is a plant flavonoid, which may find applications in the treatment of coronary heart disease, angina pectoris, cerebral thrombosis, cerebral infarction and sequelae.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN1378
BCCL3286
BCCJ5424
BCCG9193
BCCD7004

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Modulation of hepatic lipoprotein synthesis and secretion by taxifolin, a plant flavonoid
Theriault A, et al.
Journal of Lipid Research, 41, 1969-1979 (2000)
Sharad Verma et al.
Journal of molecular graphics & modelling, 37, 27-38 (2012-05-23)
Hsp90 (heat shock protein 90), a molecular chaperone, stabilizes more than 200 mutated and over expressed oncogenic proteins in cancer development. Cdc37 (cell division cycle protein 37), a co-chaperone of Hsp90, has been found to facilitate the maturation of protein
Jan Vacek et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 899, 109-115 (2012-06-06)
Liquid chromatography (LC) on various stationary phases was used for the metabolite profile analysis of quercetin, rutin, isoquercitrin and taxifolin. The metabolites were obtained using an in vitro model system of human and rat hepatocytes in the form of cell
Mathias A E Frevel et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(12), 4316-4324 (2012-09-18)
Enzogenol® pine bark extract is a dietary supplement and food ingredient produced by water extraction of Pinus radiata. We present production method, composition, and safety data from rat and dog toxicological and human clinical studies. The dry powder contains proanthocyanidins
Yuzhi Rong et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 93, 235-239 (2012-04-10)
The antioxidant capacities of the selected flavonoids quercetin, luteolin and taxifolin have been investigated at density functional level of theory with the aim of verifying the cellular antioxidant activity (CAA) values representative of experimental findings. The selected flavonoids were believed
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Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

膳食抗氧化剂

抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。

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