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Merck
CN

900690

N,N-Diisopropylethylamine

99.5%, liquid, purified by redistillation, ZerO₂®

Synonym(s):

DIPEA, N-Ethyldiisopropylamine, Ethyldiisopropylamine, ‘Hünig’s base’

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About This Item

Linear Formula:
[(CH3)2CH]2NC2H5
CAS Number:
7087-68-5
Molecular Weight:
129.24
NACRES:
NA.21
UNSPSC Code:
12352116
EC Number:
230-392-0
MDL number:
MFCD00008868
Assay:
99.5%
Form:
liquid

Key Documents

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Product Name

N,N-Diisopropylethylamine, purified by redistillation, ZerO2®, 99.5%

InChI

1S/C8H19N/c1-6-9(7(2)3)8(4)5/h7-8H,6H2,1-5H3

InChI key

JGFZNNIVVJXRND-UHFFFAOYSA-N

SMILES string

CCN(C(C)C)C(C)C

vapor pressure

31 mmHg ( 37.7 °C)

assay

99.5%

form

liquid

refractive index

n20/D 1.414 (lit.)

bp

127 °C (lit.)

mp

<−50 °C (lit.)

density

0.742 g/mL at 25 °C (lit.)

functional group

amine

Quality Level

100

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General description

N,N-Diisopropylethylamine, also known as Hünig′s base, is a sterically hindered amine. It is a non-nucleophilic base commonly employed for substitution reactions.

Application

N,N-Diisopropylethylamine may be used in the synthesis of mannosylated ovalbumin peptides.
Proton scavenger used in peptide coupling, enolboration, Pd(0)-catalyzed alkoxycarbonylation of allyl phosphates and acetates, and as a catalyst in vinyl sulfone synthesis.

Features and Benefits

ZerO2® products are rigorously degassed with highly pure inert gas providing solvents and solutions (anhydrous if specified) with very low residual oxygen content.

Legal Information

ZerO2® is a trademark of Sigma-Aldrich Co. LLC
ZerO2 is a registered trademark of Merck KGaA, Darmstadt, Germany
ZerO2 is a registered trademark of Sigma-Aldrich Co. LLC

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Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

49.1 °F

flash_point_c

9.5 °C

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
SHBT0357
SHBS6336
SHBR6877
SHBR9953
SHBR4330

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Synthetic Communications, 23, 3073-3073 (1993)
The Journal of Organic Chemistry, 58, 7162-7162 (1993)
The Journal of Organic Chemistry, 58, 1538-1538 (1993)
The Journal of Organic Chemistry, 59, 695-695 (1994)
Pavla Simerska et al.
Drug delivery and translational research, 4(3), 246-255 (2015-03-20)
Peptide-based vaccine delivery can be hampered by rapid peptidase activity and poor inherent immunogenicity. The self-adjuvanting lipid core peptide system (LCP) has been shown to confer improved stability and immunogenicity on peptide epitopes of group A Streptococcus, Chlamydia, hookworm, and

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