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Merck
CN

94334

Formononetin

analytical standard

Synonym(s):

7-Hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one, 7-Hydroxy-3-(4-methoxyphenyl)chromone, 7-Hydroxy-4′-methoxyisoflavone, Biochanin B, Daidzein 4′-methyl ether, Formonetin, Formononetol

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About This Item

Empirical Formula (Hill Notation):
C16H12O4
CAS Number:
485-72-3
Molecular Weight:
268.26
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
329770326
EC Number:
207-623-9
Beilstein/REAXYS Number:
237979
MDL number:
MFCD00016948

Key Documents

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Product Name

Formononetin, analytical standard

InChI

1S/C16H12O4/c1-19-12-5-2-10(3-6-12)14-9-20-15-8-11(17)4-7-13(15)16(14)18/h2-9,17H,1H3

InChI key

HKQYGTCOTHHOMP-UHFFFAOYSA-N

SMILES string

COc1ccc(cc1)C2=COc3cc(O)ccc3C2=O

grade

analytical standard

assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

application(s)

food and beverages

format

neat

storage temp.

2-8°C

Quality Level

100

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Application

Formononetin has been used as a reference standard for the determination of formononetin in:
  • Cow, goat, sheep and human milk samples by magnetic-micro-dispersive solid-phase extraction (m-μ-dSPE) combined with ultra-high performance liquid chromatography-triple quadrupole electrospray ionization-tandem mass spectrometry (UHPLC-QqQ-ESI-MS/MS) operating under the multiple reaction monitoring (MRM) mode of detection.
  • Dairy products by quick, easy, cheap, effective, rugged, and safe (QuEChERS) extraction procedure and UHPLC-QqQ-ESI-MS/MS with MRM mode of detection.

It may be used as a reference standard for the determination of formononetin in:
  • Natural products by turbulent flow chromatography liquid chromatography-high resolution mass spectrometry (TFC LC-HRMS).
  • Soy-drinks by gas chromatography combined with MS/MS operating on electron ionization (EI) mode.
  • Rat plasma by UHPLC-QqQ-ESI-MS/MS.

Biochem/physiol Actions

Isoflavone found in red clover. Effective against Giardia lamblia infection, at least partially by inducing detachment of trophozoites from intestinal mucosa.

General description

Formononetin belongs to the isoflavones class of polyphenols.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM7411
BCCM9435
BCCJ8308
BCCJ7737
BCCG7450

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Simultaneous determination of formononetin, calycosin and rhamnocitrin from Astragalus complanatus by UHPLC-MS-MS in rat plasma: application to a pharmacokinetic study.
Li Y, et al.
Journal of Chromatographic Science, 54(9), 1605-1612 (2016)
Development of liquid chromatography-tandem mass spectrometry method for analysis of polyphenolic compounds in liquid samples of grape juice, green tea and coffee.
Sapozhnikova Y.
Food Chemistry, 150, 87-93 (2014)
Fast derivatization procedure for the analysis of phytoestrogens in soy milk by gas chromatography tandem mass spectrometry.
Benedetti B, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 137(7), 62-70 (2018)
Multiresidue determination of estrogens in different dairy products by ultra-high-performance liquid chromatography triple quadrupole mass spectrometry.
Socas-Rodriguez B, et al.
Journal of Chromatography A, 1496(7), 58-67 (2017)
Direct analysis of prostaglandin-E2 and-D2 produced in an inflammatory cell reaction and its application for activity screening and potency evaluation using turbulent flow chromatography liquid chromatography-high resolution mass spectrometry
Shin JS, et al.
Journal of Chromatography A, 1463(7), 128-135 (2016)
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