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Merck
CN

A2428

Amcinonide

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C28H35FO7
CAS Number:
51022-69-6
Molecular Weight:
502.57
UNSPSC Code:
41116107
PubChem Substance ID:
329770783
EC Number:
256-915-2
MDL number:
MFCD00213379

Key Documents

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grade

analytical standard

Quality Level

400

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

format

neat

SMILES string

[H][C@@]12C[C@@]3([H])[C@]4([H])CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]1(OC6(CCCC6)O2)C(=O)COC(C)=O

InChI

1S/C28H35FO7/c1-16(30)34-15-22(33)28-23(35-26(36-28)9-4-5-10-26)13-20-19-7-6-17-12-18(31)8-11-24(17,2)27(19,29)21(32)14-25(20,28)3/h8,11-12,19-21,23,32H,4-7,9-10,13-15H2,1-3H3/t19-,20-,21-,23+,24-,25-,27-,28+/m0/s1

InChI key

ILKJAFIWWBXGDU-MOGDOJJUSA-N

Gene Information

human ... NR3C1(2908)

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General description

Amcinonide is a highly potent topical corticosteroid. It possesses pharmacological properties like anti-pruritic, anti-inflammatory and vasoconstrictive activity.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Lot/Batch Number
BCBX0617
BCBS2899
SLBD1126V

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Mosby's Drug Reference for Health Professions null
R Hayakawa et al.
Contact dermatitis, 12(4), 213-214 (1985-04-01)
Allergic contact dermatitis from topical corticosteroids has been regarded as rare. However, it should be considered in long-standing, resistant or worsening eczema in spite of topical steroid therapy. Cases of allergic dermatitis from amcinonide have been reported previously. We report
Drugs for the Geriatric Patient E-Book: Text with BONUS Handheld Software (2007)
A C Huntley et al.
Cutis, 35(5), 489-492 (1985-05-01)
A randomized, double-blind study compared the efficacy and safety of amcinonide and betamethasone dipropionate ointments, applied twice daily for two weeks, in the treatment of patients with moderate to severe psoriasis. Thirty-four patients were enrolled; thirty patients had had psoriasis
T Muramatsu et al.
The Journal of dermatology, 23(10), 683-688 (1996-10-01)
Six patients with pemphigoid and three patients with pemphigus foliaceus were successfully treated with topical corticosteroids. This was especially effective in cases of pretibial localized pemphigoid and in mild cases of bullous pemphigoid and pemphigus foliaceus with negative or low-titer
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