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Merck
CN

A2428

Amcinonide

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C28H35FO7
CAS Number:
51022-69-6
Molecular Weight:
502.57
UNSPSC Code:
41116107
PubChem Substance ID:
329770783
EC Number:
256-915-2
MDL number:
MFCD00213379

Key Documents

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InChI key

ILKJAFIWWBXGDU-MOGDOJJUSA-N

InChI

1S/C28H35FO7/c1-16(30)34-15-22(33)28-23(35-26(36-28)9-4-5-10-26)13-20-19-7-6-17-12-18(31)8-11-24(17,2)27(19,29)21(32)14-25(20,28)3/h8,11-12,19-21,23,32H,4-7,9-10,13-15H2,1-3H3/t19-,20-,21-,23+,24-,25-,27-,28+/m0/s1

SMILES string

[H][C@@]12C[C@@]3([H])[C@]4([H])CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]1(OC6(CCCC6)O2)C(=O)COC(C)=O

grade

analytical standard

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

format

neat

Quality Level

400

Gene Information

human ... NR3C1(2908)

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General description

Amcinonide is a highly potent topical corticosteroid. It possesses pharmacological properties like anti-pruritic, anti-inflammatory and vasoconstrictive activity.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
BCBX0617
BCBS2899
SLBD1126V

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Mosby's Drug Reference for Health Professions null
Contact allergy to amcinonide.
Y Kubo et al.
Contact dermatitis, 15(2), 109-111 (1986-08-01)
B Berman et al.
Experimental cell research, 183(1), 215-228 (1989-07-01)
Serine protease inhibitors with a specificity for trypsin inhibit interferon-gamma (INF-gamma)-induced HLA-DR expression on a hybrid human epidermal cell line (H12), dermal fibroblasts, and primary keratinocytes. Protease inhibitors with a specificity for chymotrypsin or papain fail to inhibit IFN-gamma. The
Drugs for the Geriatric Patient E-Book: Text with BONUS Handheld Software (2007)
R Hayakawa et al.
Contact dermatitis, 12(4), 213-214 (1985-04-01)
Allergic contact dermatitis from topical corticosteroids has been regarded as rare. However, it should be considered in long-standing, resistant or worsening eczema in spite of topical steroid therapy. Cases of allergic dermatitis from amcinonide have been reported previously. We report
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