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Merck
CN

A8199

N-Acetyl-L-cysteine

≥99% (TLC), suitable for cell culture, BioXtra

Synonym(s):

LNAC, NAC

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About This Item

Linear Formula:
HSCH2CH(NHCOCH3)CO2H
CAS Number:
616-91-1
Molecular Weight:
163.19
NACRES:
NA.26
PubChem Substance ID:
24891213
UNSPSC Code:
12352209
EC Number:
210-498-3
MDL number:
MFCD00004880
Beilstein/REAXYS Number:
1724426

Key Documents

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Product Name

N-Acetyl-L-cysteine, BioXtra, ≥99% (TLC)

product line

BioXtra

Quality Level

300

assay

≥99% (TLC)

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

≤0.002% Phosphorus (P), ≤0.1% Insoluble matter

ign. residue

≤0.5%

color

white to off-white

mp

106-108 °C (lit.)

solubility

H2O: 0.1 M at 20 °C, clear, colorless

cation traces

Al: ≤0.0005%, Ca: ≤0.0005%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.005%, Mg: ≤0.0005%, NH4+: ≤0.05%, Na: ≤0.1%, Pb: ≤0.001%, Zn: ≤0.0005%

application(s)

cell analysis

storage temp.

2-8°C

SMILES string

CC(=O)N[C@@H](CS)C(O)=O

InChI

1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1

InChI key

PWKSKIMOESPYIA-BYPYZUCNSA-N

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Application

N-Acetyl-L-cysteine has been used to study its protective effect against styrene-induced cochlear injuries in rats. It has also been used as a supplement in basal chemically-defined medium (BDM) for the culture of oligodendrocyte precursor cells.

Biochem/physiol Actions

Antioxidant and mucolytic agent. Increases cellular pools of free radical scavengers. Reported to prevent apoptosis in neuronal cells but induce apoptosis in smooth muscle cells. Inhibits HIV replication. May serve as a substrate for microsomal glutathione transferase.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF8150V
0000525903
0000525903
WXBF7505V
WXBF6609V

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Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination
Chen Y
PLoS ONE, 12(12), e0189380-e0189380 (2017)
Protective effect of N-acety-L-cysteine (L-NAC) against styrene-induced cochlear injuries
Wei Ping Yang
Acta Oto-Laryngologica, 129(10), 1036-1043 (2009)
Suzanne M Cloonan et al.
Journal of medicinal chemistry, 58(11), 4494-4505 (2015-05-12)
Ruthenium polypyridyl complexes show great promise as new photodynamic therapy (PDT) agents. However, a lack of detailed understanding of their mode of action in cells poses a challenge to their development. We have designed a new Ru(II) PDT candidate that
Yuval Samuni et al.
Biochimica et biophysica acta, 1830(8), 4117-4129 (2013-04-27)
N-acetylcysteine (NAC) has been in clinical practice for several decades. It has been used as a mucolytic agent and for the treatment of numerous disorders including paracetamol intoxication, doxorubicin cardiotoxicity, ischemia-reperfusion cardiac injury, acute respiratory distress syndrome, bronchitis, chemotherapy-induced toxicity
Luigi Franchi et al.
Journal of immunology (Baltimore, Md. : 1950), 193(8), 4214-4222 (2014-09-17)
The nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 3 (Nlrp3) inflammasome plays an important role in inflammation by controlling the maturation and secretion of the cytokines IL-1β and IL-18 in response to multiple stimuli including pore-forming toxins, particulate matter, and ATP.
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Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

L-Cysteine in Cell Culture

Importance and uses of cysteine in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures

L-半胱氨酸在细胞培养中的应用

半胱氨酸在无血清真核细胞培养中的重要性和应用，包括杂交瘤细胞和中国仓鼠卵巢（CHO）细胞培养

膳食抗氧化剂

抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。

Global Trade Item Number

SKUGTIN
A8199-100G04061833391280
A8199-10G04061833391297
A8199-1KG04065268456507

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