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B8800

Bacitracin zinc salt

Name: Bacitracin zinc salt
Brand: SIAL

from Bacillus licheniformis, meets USP testing specifications

Synonym(s):

Zinc bacitracin

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About This Item

Empirical Formula (Hill Notation):

C₆₆H₁₀₁N₁₇O₁₆SZn

CAS Number:

1405-89-6

Molecular Weight:

1486.07

NACRES:

NA.76

PubChem Substance ID:

24892095

UNSPSC Code:

41116107

EC Number:

215-787-8

MDL number:

MFCD00130598

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Properties

biological source

Bacillus licheniformis

Quality Level

200

agency

USP/NF, meets USP testing specifications

form

powder

mp

250 °C (dec.) (lit.)

antibiotic activity spectrum

Gram-positive bacteria

application(s)

pharmaceutical (small molecule)

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

[Zn++].CCC(C)C(N)C1=NCC(S1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC([O-])=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H]2CCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CC([O-])=O)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](Cc4ccccc4)NC(=O)[C@@H](NC(=O)[C@@H](CCCN)NC2=O)[C@@H](C)CC

InChI

1S/C66H103N17O16S.Zn/c1-9-35(6)52(69)66-72-32-48(100-66)63(97)80-43(26-34(4)5)59(93)75-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)76-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-73-39)77-60(94)44(27-38-18-13-12-14-19-38)81-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)74-56(40)90;/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,73)(H,71,89)(H,74,90)(H,75,93)(H,76,98)(H,77,94)(H,78,96)(H,79,95)(H,80,97)(H,81,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88);/q;+2/p-2/t35?,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48?,52?,53-,54-;/m0./s1

InChI key

NKULICGUDKGGRL-FCHFGNCGSA-L

Description

General description

Chemical structure: peptide

Application

Bacitracin is used to study the disruption of bacterial cell wall synthesis at the level of peptidoglycan biosynthesis and isoprenyl metabolism. Used to study the biosynthesis of sterols and squalene.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

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Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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[Problems with identification of beta-hemolytic streptococcus resistant to bacitracin isolated from patients with pharyngitis].

Alina Olender et al.

Medycyna doswiadczalna i mikrobiologia, 64(1), 1-10 (2012-07-20)

The genus Streptococcus comprises a number of species characterized by a differential pathogenic potential. These bacteria can be considered as members of microbial physiological flora but they can also cause mild infections or severe, life threatening conditions. The majority of

Cell envelope stress response in cell wall-deficient L-forms of Bacillus subtilis.

Diana Wolf et al.

Antimicrobial agents and chemotherapy, 56(11), 5907-5915 (2012-09-12)

L-forms are cell wall-deficient bacteria that can grow and proliferate in osmotically stabilizing media. Recently, a strain of the Gram-positive model bacterium Bacillus subtilis was constructed that allowed controlled switching between rod-shaped wild-type cells and corresponding L-forms. Both states can

Identification of regions important for resistance and signalling within the antimicrobial peptide transporter BceAB of Bacillus subtilis.

Felix Kallenberg et al.

Journal of bacteriology, 195(14), 3287-3297 (2013-05-21)

In the low-G+C-content Gram-positive bacteria, resistance to antimicrobial peptides is often mediated by so-called resistance modules. These consist of a two-component system and an ATP-binding cassette transporter and are characterized by an unusual mode of signal transduction where the transporter

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Global Trade Item Number

SKU	GTIN
B8800-1250KU	04061833617137
B8800-50KU	04061833443279