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C6081

9-(2-Carboxy-2-cyanovinyl)julolidine

≥98% (HPLC)

Synonym(s):

9-([E]-2-Carboxy-2-cyanovinyl)julolidine, CCVJ

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About This Item

Empirical Formula (Hill Notation):
C16H16N2O2
CAS Number:
142978-18-5
Molecular Weight:
268.31
UNSPSC Code:
12352200
MDL number:
MFCD00274408
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assay

≥98% (HPLC)

storage temp.

2-8°C

SMILES string

OC(=O)\C(=C\c1cc2CCCN3CCCc(c1)c23)C#N

InChI

1S/C16H16N2O2/c17-10-14(16(19)20)9-11-7-12-3-1-5-18-6-2-4-13(8-11)15(12)18/h7-9H,1-6H2,(H,19,20)/b14-9+

InChI key

JXENNHTVELFRHV-NTEUORMPSA-N

Application

Fluorescent probe for binding to proteins etc., quantum yield increases by decreasing free rotation: fluorescent molecular rotor.

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
075H1082

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T Iio et al.
Journal of biochemistry, 113(2), 196-199 (1993-02-01)
1-(2-Hydroxyethyl)-6-[(2,2-dicyano)vinyl]-2,3,4-trihydroquinoli ne (DCQ) is a fluorescent dye and its fluorescence yield is determined by a freedom of intramolecular rotation. When DCQ was added to an actin solution, its fluorescence intensity increased as the actin molecule transformed from G-actin to F-actin.
T Iwaki et al.
Biochemistry, 32(29), 7589-7592 (1993-07-27)
We have prepared monoclonal antibodies for the fluorescent molecular rotors 9-(2-carboxy-2-cyanovinyl)julolidine (CCVJ) and 9-(dicyanovinyl)julolidine (DCVJ). Mouse monoclonal antibody (IgG2b) prepared against CCVJ-conjugated bovine serum albumin strongly bound CCVJ and DCVJ. The CCVJ (or DCVJ) binding to IgG and Fab was