D0501
4-Deoxypyridoxine hydrochloride
analytical standard
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About This Item
Empirical Formula (Hill Notation):
C8H11NO2 · HCl
CAS Number:
Molecular Weight:
189.64
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
205-714-8
MDL number:
biological source
synthetic (organic)
Quality Level
grade
analytical standard
assay
≥98%
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
color
white to yellow
mp
263-265 °C
application(s)
forensics and toxicology
veterinary
vitamins, nutraceuticals, and natural products
format
neat
storage temp.
−20°C
SMILES string
Cl.Cc1ncc(CO)c(C)c1O
InChI
1S/C8H11NO2.ClH/c1-5-7(4-10)3-9-6(2)8(5)11;/h3,10-11H,4H2,1-2H3;1H
InChI key
QZKKOQQIVLXUEI-UHFFFAOYSA-N
General description
4-Deoxypyridoxine hydrochloride is a strong antagonist of vitamin B6.
Application
4-Deoxypyridoxine hydrochloride analytical standard can be used as follows:
- Development of a reversed-phase high-performance liquid chromatographic (RP-HPLC) method combined with mass spectrometric (MS) detection for the impurity analysis of metadoxine drug
- As an internal standard in the ultra- and high- performance liquid chromatographic analysis of pyridoxine in multivitamin tablet samples coupled with UV, mass spectrometric, and fluorescence detector
Other Notes
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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A Trakatellis et al.
Postgraduate medical journal, 68 Suppl 1, S70-S77 (1992-01-01)
Measurements of serine hydroxymethyltransferase (SHMT) in resting lymphocyte cultures showed that the level of activity of this enzyme was very low. Under the influence of mitogenic stimuli serine hydroxymethyl-transferase activity was induced 5-20-fold. Addition in the cultures of 4-deoxypyridoxine, a
J Scountzou et al.
Immunopharmacology and immunotoxicology, 11(4), 657-666 (1989-01-01)
We studied the effect of pyridoxine deficiency state on the responses of human lymphocytes to certain mitogenic factors. Deoxypyridoxine (DB6), a potent pyridoxine antagonist, considerably inhibited Bromodeoxyuridine (BrdU) incorporation into the newly synthesized DNA of lymphocytes cultured with Phytohemagglutinin (PHA)
S P Coburn et al.
The Journal of nutrition, 119(2), 181-188 (1989-02-01)
In previous work identification of urinary metabolites of 4'-deoxypyridoxine which had been oxidized in the 5'-position and long-term dilution of labeled urinary metabolites with unlabeled molecules suggested possible microbial contributions. In the current studies germfree guinea pigs were able to
V E Allgood et al.
The Journal of biological chemistry, 265(21), 12424-12433 (1990-07-25)
We have examined the influence of intracellular vitamin B6 concentration on glucocorticoid receptor function in HeLa S3 cells transfected with a glucocorticoid-responsive chloramphenicol acetyltransferase (CAT) reporter plasmid. CAT activity is induced from this plasmid specifically by glucocorticoid hormones in a
Anja Lüth et al.
Analytica chimica acta, 722, 70-79 (2012-03-27)
Sphingosine-1-phosphate lyase (SPL) is the only known enzyme that irreversibly cleaves sphingosine-1-phosphate (S1P) into phosphoethanolamine and (2E)-hexadecenal during the final step of sphingolipid catabolism. Because S1P is involved in a wide range of physiological and diseased processes, determining the activity
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