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Merck
CN

N7889

Nicergoline

analytical standard, for drug analysis

Synonym(s):

5-Bromonicotinic acid 10-methoxy-1,6-dimethylergoline-8-methyl ester

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About This Item

Empirical Formula (Hill Notation):
C24H26BrN3O3
CAS Number:
27848-84-6
Molecular Weight:
484.39
NACRES:
NA.24
PubChem Substance ID:
329818675
UNSPSC Code:
41116107
EC Number:
248-694-6
MDL number:
MFCD00869626

Key Documents

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Quality Level

100

grade

analytical standard

assay

≥97% (TLC)

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

SMILES string

[H][C@@]12Cc3cn(C)c4cccc(c34)[C@]1(C[C@@H](COC(=O)c5cncc(Br)c5)CN2C)OC

InChI

1S/C24H26BrN3O3/c1-27-13-17-8-21-24(30-3,19-5-4-6-20(27)22(17)19)9-15(12-28(21)2)14-31-23(29)16-7-18(25)11-26-10-16/h4-7,10-11,13,15,21H,8-9,12,14H2,1-3H3/t15-,21-,24+/m1/s1

InChI key

YSEXMKHXIOCEJA-FVFQAYNVSA-N

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General description

Nicergoline is an ergot derivative, which may be used in the treatment of affective, cognitive and behavioral disorders seen in older people. It is an α -adrenergic antagonist that may be used for companion animals like cats and dogs to treat, behavioral disorders, problems with aging, excessive vocaliztion and restessness.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Cerebral and peripheral vasodilator

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL6179
BCCK3706
BCCJ0185
BCCJ7004
BCCG0100

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Nicergoline for dementia and other age associated forms of cognitive impairment
MF and LF
Cochrane database of systematic reviews (Online), 2001-2001 null
Maddison.EJ, et al.
Small Animal Clinical Pharmacology (2008)
Antonio Moschetta et al.
Journal of lipid research, 46(10), 2221-2232 (2005-08-03)
Biliary lipids (bile salts, phospholipids, cholesterol, plant sterols) were determined in 89 vertebrate species (cartilaginous and bony fish, reptiles, birds, and mammals), and individual phospholipid classes were measured in 35 species. All samples contained conjugated bile salts (C(27) bile alcohol
Tetsuya Mizuno et al.
Brain research, 1066(1-2), 78-85 (2005-12-06)
We examined the neuroprotective role of nicergoline in neuron-microglia or neuron-astrocytes co-cultures. Nicergoline, an ergoline derivative, significantly suppressed the neuronal cell death induced by co-culture with activated microglia or astrocytes stimulated with lipopolysaccharide (LPS) and interferon (IFN)-gamma. To elucidate the
Mohamed I Walash et al.
Journal of AOAC International, 91(2), 349-359 (2008-05-15)
A rapid, simple, and highly sensitive second-derivative synchronous fluorometric method has been developed for the simultaneous analysis of binary mixtures of cinnarizine (CN) and nicergoline (NIC). The method is based upon measurement of the native fluorescence of these drugs at
View All Related Papers

Global Trade Item Number

SKUGTIN
N7889-100MG04061832851068

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