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P0597

Pilocarpine nitrate

Name: Pilocarpine nitrate
Brand: SIAL

meets USP testing specifications

Synonym(s):

Pilocarpine nitrate salt

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₆N₂O₂ · HNO₃

CAS Number:

148-72-1

Molecular Weight:

271.27

UNSPSC Code:

41116107

NACRES:

NA.21

PubChem Substance ID:

24898116

EC Number:

205-723-7

Beilstein/REAXYS Number:

4171406

MDL number:

MFCD00078497

Form:

crystals

Quality level:

200

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Quality Level

200

agency

USP/NF, meets USP testing specifications

form

crystals

application(s)

pharmaceutical (small molecule)

SMILES string

O[N+]([O-])=O.CC[C@H]1[C@H](COC1=O)Cc2cncn2C

InChI

1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1

InChI key

PRZXEPJJHQYOGF-GNAZCLTHSA-N

Gene Information

human ... CHRM1(1128), CHRM3(1131)

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Biochem/physiol Actions

Nonselective muscarinic acetylcholine receptor agonist.

Nonselective muscarinic acetylcholine receptor agonist; used to produce an experimental model of epilepsy.

pictograms

GHS03,GHS06

signalword

Danger

hcodes

H272,H302,H330

pcodes

P210 - P220 - P260 - P264 - P301 + P312 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Ox. Sol. 2

Storage Class

5.1B - Oxidizing hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

涉药品监管产品

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Nrf2 defense pathway: Experimental evidence for its protective role in epilepsy.

Manuela Mazzuferi et al.

Annals of neurology, 74(4), 560-568 (2013-05-21)

Epigenetic mechanisms involved in transcriptional regulation of multiple molecular pathways are potentially attractive therapeutic interventions for epilepsy, because single target therapies are unlikely to provide both anticonvulsant and disease-modifying effects. A selection of epilepsy-related gene expression data sets were retrieved

Electrical stimulation of left anterior thalamic nucleus with high-frequency and low-intensity currents reduces the rate of pilocarpine-induced epilepsy in rats.

Shuo-Bin Jou et al.

Seizure, 22(3), 221-229 (2013-01-15)

Bilateral electrical stimulation of anterior nuclei of thalamus (ANT) has shown promising effects on epileptic seizures. However, bilateral implantation increases the risk of surgical complications and side effects. This study was undertaken to access the effectiveness of a stimulation paradigm

High-dose rapamycin blocks mossy fiber sprouting but not seizures in a mouse model of temporal lobe epilepsy.

Kathleen Heng et al.

Epilepsia, 54(9), 1535-1541 (2013-07-16)

The role of granule cell axon (mossy fiber) sprouting in temporal lobe epileptogenesis is unclear and controversial. Rapamycin suppresses mossy fiber sprouting, but its reported effects on seizure frequency are mixed. The present study used high-dose rapamycin to more completely

Astrocyte control of synaptic NMDA receptors contributes to the progressive development of temporal lobe epilepsy.

Jerome Clasadonte et al.

Proceedings of the National Academy of Sciences of the United States of America, 110(43), 17540-17545 (2013-10-09)

Astrocytes modulate neuronal activity, synaptic transmission, and behavior by releasing chemical transmitters in a process termed gliotransmission. Whether this process impacts epilepsy in vivo is not known. We show that genetic impairment of transmitter release from astrocytes by the expression

Status epilepticus enhances tonic GABA currents and depolarizes GABA reversal potential in dentate fast-spiking basket cells.

Jiandong Yu et al.

Journal of neurophysiology, 109(7), 1746-1763 (2013-01-18)

Temporal lobe epilepsy is associated with loss of interneurons and inhibitory dysfunction in the dentate gyrus. While status epilepticus (SE) leads to changes in granule cell inhibition, whether dentate basket cells critical for regulating granule cell feedforward and feedback inhibition

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Global Trade Item Number

SKU	GTIN
P0597-25G	04061835516728
P0597-5G	04061833612521

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