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P2940000

Primaquine diphosphate

Name: Primaquine diphosphate
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Primaquine bisphosphate, 8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline diphosphate salt, Primaquine diphosphate salt

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₂₁N₃O · 2H₃PO₄

CAS Number:

63-45-6

Molecular Weight:

455.34

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329820156

MDL number:

MFCD00013166

Beilstein/REAXYS Number:

3812133

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Properties

grade

pharmaceutical primary standard

API family

primaquine

manufacturer/tradename

EDQM

mp

205-206 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OP(O)(O)=O.OP(O)(O)=O.COc1cc(NC(C)CCCN)c2ncccc2c1

InChI

1S/C15H21N3O.2H3O4P/c1-11(5-3-7-16)18-14-10-13(19-2)9-12-6-4-8-17-15(12)14;2*1-5(2,3)4/h4,6,8-11,18H,3,5,7,16H2,1-2H3;2*(H3,1,2,3,4)

InChI key

GJOHLWZHWQUKAU-UHFFFAOYSA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Primaquine diphosphate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H341,H361fd

pcodes

P202 - P264 - P280 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral - Muta. 2 - Repr. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Glucose-6-phosphate dehydrogenase deficiency A- variant in febrile patients in Haiti.

Tamar E Carter et al.

The American journal of tropical medicine and hygiene, 91(2), 412-414 (2014-06-04)

Haiti is one of two remaining malaria-endemic countries in the Caribbean. To decrease malaria transmission in Haiti, primaquine was recently added to the malaria treatment public health policy. One limitation of primaquine is that, at certain doses, primaquine can cause

Scalable preparation and differential pharmacologic and toxicologic profiles of primaquine enantiomers.

N P Dhammika Nanayakkara et al.

Antimicrobial agents and chemotherapy, 58(8), 4737-4744 (2014-06-11)

Hematotoxicity in individuals genetically deficient in glucose-6-phosphate dehydrogenase (G6PD) activity is the major limitation of primaquine (PQ), the only antimalarial drug in clinical use for treatment of relapsing Plasmodium vivax malaria. PQ is currently clinically used in its racemic form.

Interactive medical case. A chilly fever.

Amanda J Redig et al.

The New England journal of medicine, 371(16), e24-e24 (2014-10-16)

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Global Trade Item Number

SKU	GTIN
P2940000	04061834366423