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PHR1021

Clindamycin Phosphate

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Clindamycin 2-phosphate, Clindamycin 2-dihydrogen phosphate

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About This Item

Empirical Formula (Hill Notation):
C18H34ClN2O8PS
CAS Number:
24729-96-2
Molecular Weight:
504.96
NACRES:
NA.24
PubChem Substance ID:
329823052
UNSPSC Code:
41116107
EC Number:
246-433-0
MDL number:
MFCD07793328
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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. C2269000, traceable to USP 1138008

API family

clindamycin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

SMILES string

CCC[C@@H]1C[C@H](N(C)C1)C(=O)NC([C@H](C)Cl)C2O[C@H](SC)[C@H](OP(O)(O)=O)[C@@H](O)[C@H]2O

InChI

1S/C18H34ClN2O8PS/c1-5-6-10-7-11(21(3)8-10)17(24)20-12(9(2)19)15-13(22)14(23)16(18(28-15)31-4)29-30(25,26)27/h9-16,18,22-23H,5-8H2,1-4H3,(H,20,24)(H2,25,26,27)/t9-,10+,11-,12?,13+,14-,15?,16+,18+/m0/s1

InChI key

UFUVLHLTWXBHGZ-MWBQRTRKSA-N

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Clindamycin is a common antibiotic drug generally employed for the treatment of infections caused by gram-positive aerobes and both gram-negative and gram-positive anaerobic pathogens.

Application

Clindamycin Phosphate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and potentiometry techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Spectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria.
Mode of Action: Inhibits protein synthesis in bacterial by binding the 50s ribosomal subunit.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

Antibacterial and antiprotozoal antibiotic of the licosamide class.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC4009 in the slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Lact. - Skin Sens. 1

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品

This item has

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nonisothermal stability assessment of stable pharmaceuticals: testing of a clindamycin phosphate formulation
Kipp JE and Hlavaty JJ
Pharmaceutical Research, 8(5), 570-575 (1991)
High-performance liquid chromatography of clindamycin antibiotics using tris (bipyridine)-ruthenium (III) chemiluminescence detection
Targove MA and Danielson ND
Journal of Chromatographic Science, 28(10), 505-509 (1990)
Sub-second adsorption for the fast sub-nanomolar monitoring of Clindamycin in its pure and pharmaceutical samples by fast Fourier transformation with the use of continuous cyclic voltammetry at an Au microelectrode in a flowing system
Norouzi P, et al.
Materials Science and Engineering, C, 28(1), 87-93 (2008)
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Global Trade Item Number

SKUGTIN
PHR1021-1G04061835236930