Skip to Content
Merck
CN

Key Documents

View All Documentation

PHR1156

Tributyl 2-acetylcitrate

greener alternative

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Acetyl tributyl citrate

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Linear Formula:
CH3CO2C[CO2(CH2)3CH3][CH2CO2(CH2)3CH3]2
CAS Number:
77-90-7
Molecular Weight:
402.48
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823174
EC Number:
201-067-0
Beilstein/REAXYS Number:
2303316
MDL number:
MFCD00043554
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0001055, traceable to USP 1009901

vapor pressure

0.26 psi ( 20 °C), 0.8 psi ( 55 °C)

description

API family: acetyltributyl citrate

API family

acetyltributyl citrate

CofA

current certificate can be downloaded

greener alternative product characteristics

Less Hazardous Chemical Syntheses
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

refractive index

n20/D 1.443 (lit.)

density

1.05 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

greener alternative category

Aligned

storage temp.

2-30°C

SMILES string

CCCCOC(=O)CC(CC(=O)OCCCC)(OC(C)=O)C(=O)OCCCC

InChI

1S/C20H34O8/c1-5-8-11-25-17(22)14-20(28-16(4)21,19(24)27-13-10-7-3)15-18(23)26-12-9-6-2/h5-15H2,1-4H3

InChI key

QZCLKYGREBVARF-UHFFFAOYSA-N

General description

Tributyl 2-acetylcitrate is a hydrophobic biodegradable plasticizer, that is usually synthesized by esterification of citric acid. Pharmaceutically, it is used as an excipient, which is generally applied as a thin film over the tablets or capsules.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. This product is environmentally-benign and can replace highly toxic phthalates in membrane preparation and thus aligns with "Less Hazardous Chemical Syntheses". Click here for more information.

Application

Tributyl 2-acetylcitrate may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by gas chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA8991 in the slot below. This is an example certificate only and may not be the lot that you receive.
Values of analytes vary lot to lot.

Still not finding the right product?

Explore all of our products under Tributyl 2-acetylcitrate

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

422.6 °F - closed cup

flash_point_c

217 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Study of the migration behavior of acetyl tributyl citrate from PVDC/PVC film into fish fillets as affected by intermediate doses of electron beam radiation
Zygoura PD, et al.
European Food Research and Technology, 232(6), 1017-1025 (2011)
Pharmacokinetic Properties of Acetyl Tributyl Citrate, a Pharmaceutical Excipient
Kim H, et al.
Pharmaceutics, 10(4), 177-177 (2018)
Acetyltributyl Citrate
Pharmacopeia, US
United States Pharmacopeia/National Formulary, 35(6)(4), 5555-5555 (2018)
View All Related Papers

Global Trade Item Number

SKUGTIN
PHR1156-1G04061834413592