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PHR1341

Saccharin

Name: Saccharin
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Saccharin, 2,3-Dihydroxy-1,2-benzisothiazol-3-one-1,1-dioxide, 2-Sulfobenzoic acid imide, o-Benzoic sulfimide

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About This Item

Empirical Formula (Hill Notation):

C₇H₅NO₃S

CAS Number:

81-07-2

Molecular Weight:

183.18

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329823326

EC Number:

201-321-0

Beilstein/REAXYS Number:

6888

MDL number:

MFCD00005866

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Properties

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. S0040000, traceable to USP 1607007

API family

saccharin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

226-229 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

O=C1NS(=O)(=O)c2ccccc12

InChI

1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)

InChI key

CVHZOJJKTDOEJC-UHFFFAOYSA-N

Description

General description

Saccharin is a well-known non-carbohydrate, sulfonyl amide artificial sweetener and is generally used in the form of its calcium or sodium salt. It possesses a sweetening power of about 550 times more than that of saccharose. On losing the acidic imino hydrogen, it forms the corresponding nitro anion, which exhibits interesting coordination chemistry. It offers a bitter and metallic aftertaste which limits its use as an artificial sweetening agent.

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.

Application

Saccharin can be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatographic and spectrophotometric techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

A sweet tastant for mammals. A glycerol taste receptor binding site specific for glucose has been proposed in drosophila.

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAC3561 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Saccharin analysis in pharmaceutical and cosmetic preparations by derivative ultraviolet spectrophotometry

Vianna-Soares CD and Martins JLS

Brazilian Journal of Pharmaceutical Sciences , 38(4), 471-478 (2002)

Bitter taste receptors for saccharin and acesulfame K

Kuhn C, et al.

The Journal of Neuroscience, 24(45), 10260-10265 (2004)

Metal complexes of saccharin

Baran EJ and Yilmaz VT

Coordination Chemistry Reviews, 250(15-16), 1980-1999 (2006)

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Global Trade Item Number

SKU	GTIN
PHR1341-1G	04061835233724