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Y0000317

Mesna impurity D

Name: Mesna impurity D
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

2,2′-Dithiobisethanesulfonic acid, 2,2′-(Disulphanediyl)bis(ethanesulphonic acid)

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About This Item

Empirical Formula (Hill Notation):

C₄H₁₀O₆S₄

CAS Number:

45127-11-5

Molecular Weight:

282.38

UNSPSC Code:

41116107

NACRES:

NA.24

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Properties

grade

pharmaceutical primary standard

API family

mesna

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[Na+].[Na+].[S](=O)(=O)([O-])CCSSCC[S](=O)(=O)[O-]

InChI

1S/C4H10O6S4.2Na/c5-13(6,7)3-1-11-12-2-4-14(8,9)10;;/h1-4H2,(H,5,6,7)(H,8,9,10);;/q;2*+1/p-2

InChI key

KQYGMURBTJPBPQ-UHFFFAOYSA-L

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Mesna impurity D EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Phase I and pharmacokinetic study of the novel chemoprotector BNP7787 in combination with cisplatin and attempt to eliminate the hydration schedule.

E Boven et al.

British journal of cancer, 92(9), 1636-1643 (2005-04-21)

BNP7787 (disodium 2,2'-dithio-bis-ethane sulphonate; Tavocept) is a novel agent developed to protect against cisplatin (cis-diammine-dichloroplatinum(II))-associated chronic toxicities. In this study, we determined the recommended dose of BNP7787 when preceding a fixed dose of cisplatin, the pharmacokinetics (PKs) and the possible

Possible (enzymatic) routes and biological sites for metabolic reduction of BNP7787, a new protector against cisplatin-induced side-effects.

Miranda Verschraagen et al.

Biochemical pharmacology, 68(3), 493-502 (2004-07-10)

Disodium 2,2'-dithio-bis-ethane sulfonate (BNP7787) is under investigation as a potential new chemoprotector against cisplatin-induced nephrotoxicity. The selective protection of BNP7787 appears to arise from the preferential uptake of the drug in the kidneys, where BNP7787 would undergo intracellular conversion into

BNP-7787 (BioNumerik/Baxter Oncology/Grelan).

R Todd Reilly

IDrugs : the investigational drugs journal, 7(1), 64-69 (2004-01-20)

BioNumerik Pharmacology Inc, Baxter Oncology GmbH (formerly ASTA Medica AG) and Grelan Pharmaceutical Co Ltd are developing BNP-7787 for the potential reduction of toxicity associated with cisplatin and carboplatin treatment in cancer patients.

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Global Trade Item Number

SKU	GTIN
Y0000317	04061833803073