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Y0001127

Phentolamine mesilate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Phentolamine methanesulfonate salt, 2-(N-[m-Hydroxyphenyl]-p-toluidinomethyl)imidazoline

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About This Item

Linear Formula:
C17H19N3O · CH3SO3H
CAS Number:
65-28-1
Molecular Weight:
377.46
NACRES:
NA.24
PubChem Substance ID:
329831277
UNSPSC Code:
41116107
MDL number:
MFCD00134201
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grade

pharmaceutical primary standard

API family

phentolamine

manufacturer/tradename

EDQM

mp

180-182 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CS(O)(=O)=O.Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3

InChI

1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)

InChI key

OGIYDFVHFQEFKQ-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Phentolamine mesilate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

α-Adrenergic receptor antagonist; peripheral vasodilator.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Xianming Su et al.
Journal of cardiovascular pharmacology, 65(1), 62-71 (2014-09-30)
Previous studies have found that Danhong injection (DHI), an extensively used herbal extract preparation in China, might be a powerful vasodilator. The aims of this study were to determine the vascular activity of DHI and its effects on arteries of

Global Trade Item Number

SKUGTIN
Y000112704061833797112