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I0775010

Isosorbide mononitrate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

1,4:3,6-Dianhydro-D-glucitol 5-nitrate

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About This Item

Empirical Formula (Hill Notation):
C6H9NO6
CAS Number:
16051-77-7
Molecular Weight:
191.14
UNSPSC Code:
41116107
EC Number:
240-197-2
NACRES:
NA.24
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grade

pharmaceutical primary standard

API family

isosorbide

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[N+](=O)([O-])O[C@H]1[C@H]2OC[C@@H]([C@H]2OC1)O

InChI

1S/C6H9NO6/c8-3-1-11-6-4(13-7(9)10)2-12-5(3)6/h3-6,8H,1-2H2/t3-,4+,5+,6+/m0/s1

InChI key

YWXYYJSYQOXTPL-SLPGGIOYSA-N

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Isosorbide mononitrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Flame
GHS02

signalword

Danger

hcodes

H228

Hazard Classifications

Flam. Sol. 1

Storage Class

4.1A - Other explosive hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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U W Abshagen
The American journal of cardiology, 70(17), 61G-66G (1992-11-27)
Pharmacokinetic studies show that isosorbide mononitrate is rapidly absorbed after oral administration, reaches peak concentrations within an hour, undergoes no significant first-pass metabolism, and is virtually 100% bioavailable. The half-life is approximately 5 hours, the volume of distribution is 0.62
Francesca Fabrizi et al.
Journal of enzyme inhibition and medicinal chemistry, 27(1), 138-147 (2011-08-06)
The clinically used sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitor dorzolamide (DRZ), a new sulfonamide CA inhibitor also incorporating NO-donating moieties, NCX250, and isosorbide mononitrate (ISMN) (an NO-donating compound with no CA inhibitory properties) were investigated for their intraocular pressure
Athanasios Mousiolis et al.
Contraception, 88(1), 41-44 (2013-01-08)
Isosorbide mononitrate (IMN) administration is thought to enhance in the cervical ripening process. We sought to identify the clinical usefulness and safety of IMN administration for shortening the time to termination of the second trimester pregnancy procedures when used in
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Global Trade Item Number

SKUGTIN
I077501004061833847220