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Merck
CN

P5555

Puerarin

analytical standard

Synonym(s):

8-(β-D-Glucopyranosyl-7-hydroxy-3- (4-hydroxyphenyl)-4H-1-benzopyran-4-one, Kakonein

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About This Item

Empirical Formula (Hill Notation):
C21H20O9
CAS Number:
3681-99-0
Molecular Weight:
416.38
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329820231
MDL number:
MFCD00076007
Beilstein/REAXYS Number:
64198

Key Documents

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InChI

1S/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2/t14-,17-,18+,19-,21+/m1/s1

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c2c(O)ccc3C(=O)C(=COc23)c4ccc(O)cc4

InChI key

HKEAFJYKMMKDOR-VPRICQMDSA-N

grade

analytical standard

assay

~80% (HPLC)

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

food and beverages
forensics and toxicology
veterinary

format

neat

Quality Level

100

Gene Information

mouse ... Aldh1a2(19378), Maoa(17161)

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Application

Puerarin may be used as a reference standard for the determination of puerarin in rat plasma after administration of puerariae radix isoflavone, using high performance liquid chromatography (HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ1813
MKCR7658
MKCN0894
WXBD0486V
MKCG6104

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HPLC method for the determination and pharmacokinetic studies on puerarin in cerebral ischemia reperfusion rat plasma after intravenous administration of puerariae radix isoflavone
Yan B, et al.
Journal of Pharmaceutical and Biomedical Analysis, 37(2), 297-301 (2005)
Benguo Liu et al.
Journal of agricultural and food chemistry, 60(51), 12501-12507 (2012-12-12)
Puerarin is a natural isoflavone, found in the Chinese medicinal plant Ge-gen, with many reported health-promoting properties. However, its low water solubility impedes its application in pharmaceutical and functional food products. This study explores the formation of inclusion complex between
Jia-Wei Wang et al.
The Journal of surgical research, 186(1), 328-337 (2013-10-02)
A wealth of evidence has suggested that oxidative stress is involved in the secondary brain injury after traumatic brain injury (TBI). Recently, numerous in vivo and in vitro studies were reported that puerarin could inhibit oxidative stress through the activation
Li Jiang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 915-916, 8-12 (2013-01-15)
Gastrodin (Gas) and puerarin (Pur) are bioactive substances derived from traditional Chinese medicine Gastrodia elata and Radix Puerariae, respectively, which were often used together in Chinese clinical prescriptions. Their injections were used in combined way for treatment of some cardiocerebrovascular
Y Zou et al.
Free radical research, 47(1), 55-63 (2012-10-24)
Current evidence suggests that amyloid beta (Aβ) peptides may play a major role in the pathogenesis of Alzheimer's disease in part by eliciting oxidative stress. Puerarin, a major isoflavone glycoside from Kudzu root (Pueraria lobata), has been reported to exert
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