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S0360090

(RS)-Selegiline hydrochloride

Name: (<I>RS</I>)-Selegiline hydrochloride
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₇N · HCl

CAS Number:

2079-54-1

Molecular Weight:

223.74

UNSPSC Code:

41116107

NACRES:

NA.24

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Properties

grade

pharmaceutical primary standard

API family

selegiline

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl.N(C(Cc1ccccc1)C)(CC#C)C

InChI

1S/C13H17N.ClH/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13;/h1,5-9,12H,10-11H2,2-3H3;1H

InChI key

IYETZZCWLLUHIJ-UHFFFAOYSA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

(RS)-Selegiline hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Regulatory Information

监管及禁止进口产品

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Switch from selegiline to rasagiline is beneficial in patients with Parkinson's disease.

Thomas Müller et al.

Journal of neural transmission (Vienna, Austria : 1996), 120(5), 761-765 (2012-12-01)

The objective of this study is to demonstrate that application of rasagiline instead of selegiline with concomitant determination of L-amphetamine and L-methamphetamine in plasma is safe and well tolerated and influences sleep, mood, and motor behavior in patients with Parkinson's

Revelation in the neuroprotective functions of rasagiline and selegiline: the induction of distinct genes by different mechanisms.

Makoto Naoi et al.

Expert review of neurotherapeutics, 13(6), 671-684 (2013-06-07)

In Parkinson's disease, cell death of dopamine neurons in the substantia nigra progresses and neuroprotective therapy is required to halt neuronal loss. In cellular and animal models, selegiline [(-)deprenyl] and rasagiline, inhibitors of type B monoamine oxidase (MAO)-B, protect neuronal

Loss of schooling behavior in cavefish through sight-dependent and sight-independent mechanisms.

Johanna E Kowalko et al.

Current biology : CB, 23(19), 1874-1883 (2013-09-17)

Surface populations of Astyanax mexicanus, living in rivers like their common ancestors, school, while several, independently derived cave populations of the same species have lost schooling behavior. We quantify schooling behavior in individual A. mexicanus and identify quantitative trait loci (QTL)

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Global Trade Item Number

SKU	GTIN
S0360090	04061836830229