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Merck
CN

Y0000042

Josamycin propionate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Leucomycin V 3-acetate 4B-(3-methylbutanoate) 2A-propanoate

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About This Item

Empirical Formula (Hill Notation):
C45H73N1O16
CAS Number:
31674-19-8
Molecular Weight:
884.06
UNSPSC Code:
41116107
NACRES:
NA.24

Key Documents

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SMILES string

N(C1C(C(OC(C1OC3OC(C(C(C3)(O)C)OC(=O)CC(C)C)C)C)OC2C(C(CC(=O)OC(C\C=C\C=C/C(C(CC2CC=O)C)O)C)OC(=O)C)OC)OC(=O)CC)(C)C

InChI

1S/C45H73NO16/c1-13-34(50)59-42-38(46(10)11)39(61-37-24-45(9,53)43(29(7)56-37)60-35(51)21-25(2)3)28(6)57-44(42)62-40-31(19-20-47)22-26(4)32(49)18-16-14-15-17-27(5)55-36(52)23-33(41(40)54-12)58-30(8)48/h14-16,18,20,25-29,31-33,37-44,49,53H,13,17,19,21-24H2,1-12H3/b15-14+,18-16-

InChI key

NBWASFCRCRXRKF-HHKVLAKUSA-N

grade

pharmaceutical primary standard

API family

josamycin

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

shipped in

wet ice

storage temp.

−20°C

Related Categories

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Josamycin propionate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Regulatory Information

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M Ducci et al.
International journal of clinical pharmacology research, 4(3), 195-199 (1984-01-01)
In this study a new high-pressure liquid chromatographic method for monitoring plasma levels of josamycin is described. Josamycin propionate was used as the internal standard. After being extracted from plasma by chloroform at an alkaline pH, the compounds were easily
Cindy Govaerts et al.
Journal of mass spectrometry : JMS, 39(4), 437-446 (2004-04-23)
Coupled liquid chromatography and ion trap mass spectrometry (LC/MS) was used for the characterization of the semi-synthetic 16-membered ring macrolide josamycin propionate. On-line identification of impurities in this antibiotic complex was performed with an ion trap mass spectrometer without recourse
G Privitera et al.
International journal of clinical pharmacology research, 4(3), 201-207 (1984-01-01)
Josamycin propionate, a tasteless josamycin derivative suitable for the preparation of paediatric oral suspension, was employed in a large, multicentre clinical study aimed at evaluating the effectiveness and safety of the drug. Two hundred paediatric practitioners participated in the study

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