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About This Item
Empirical Formula (Hill Notation):
C9H12ClN5O
CAS Number:
Molecular Weight:
241.68
UNSPSC Code:
41116107
NACRES:
NA.24
grade
pharmaceutical primary standard
API family
moxonidine
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
Clc1nc(nc(c1N=C2NCCN2)OC)C
InChI
1S/C9H12ClN5O/c1-5-13-7(10)6(8(14-5)16-2)15-9-11-3-4-12-9/h3-4H2,1-2H3,(H2,11,12,15)
InChI key
WPNJAUFVNXKLIM-UHFFFAOYSA-N
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Moxonidine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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P Ernsberger
Journal of cardiovascular pharmacology, 35(7 Suppl 4), S27-S41 (2001-05-11)
The I1-imidazoline receptor is a novel neurotransmitter receptor found mainly in the brainstem, adrenal medulla and kidney. The actions of moxonidine are described at the level of individual biomolecules, cells, tissues, organs and finally with integrative functions. The receptor functions
Scintigraphic diagnosis of Erdheim-Chester disease.
Hans Balink et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29(16), e470-e472 (2011-03-23)
Angelita Maria Stabile et al.
Life sciences, 88(11-12), 493-503 (2011-02-01)
Heart failure is a progressive deterioration in heart function associated with overactivity of the sympathetic nervous system. The benefit of inhibition of sympathetic activity by moxonidine, a centrally acting imidazoline receptor agonist, was questioned based on the outcome of a
P A van Zwieten
Journal of hypertension, 15(2), 117-125 (1997-02-01)
Clonidine, guanfacine, guanabenz and alpha-methyl-dioxyphenylalanine (DOPA), the prototypes of centrally acting antihypertensives, are assumed to induce peripheral sympathoinhibition and a reduction in blood pressure via the stimulation of alpha2-adrenoceptors in the brain stem. More recently, central imidazoline (I1)-receptors have been
Rachel J Smith et al.
Biological psychiatry, 70(8), 712-719 (2011-07-26)
Drug-associated cues can elicit stress-like responses in addicted individuals, indicating that cue- and stress-induced drug relapse may share some neural mechanisms. It is unknown whether α(2) adrenergic receptor agonists, which are known to attenuate stress-induced reinstatement of drug seeking in
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