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Merck
CN

Y0001151

Hydrastine hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(1R,9S)-β-Hydrastine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C21H21NO6 · HCl
CAS Number:
5936-28-7
Molecular Weight:
419.86
NACRES:
NA.24
PubChem Substance ID:
329831282
UNSPSC Code:
41116107
MDL number:
MFCD00058100

Key Documents

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Product Name

Hydrastine hydrochloride, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C21H21NO6.ClH/c1-22-7-6-11-8-15-16(27-10-26-15)9-13(11)18(22)19-12-4-5-14(24-2)20(25-3)17(12)21(23)28-19;/h4-5,8-9,18-19H,6-7,10H2,1-3H3;1H/t18-,19+;/m1./s1

SMILES string

Cl.COc1ccc2[C@H](OC(=O)c2c1OC)[C@@H]3N(C)CCc4cc5OCOc5cc34

InChI key

URBFHJWLYXILMP-VOMIJIAVSA-N

grade

pharmaceutical primary standard

API family

hydrastine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

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Related Categories

Application

Hydrastine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Tyrosine hydroxylase inhibitor. Reduces dopamine content in PC12 cells.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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V Tonkovic-Capin et al.
Journal of neurophysiology, 86(5), 2363-2373 (2001-11-08)
The discharge patterns of respiratory neurons of the caudal ventral respiratory group (cVRG) appear to be subject to potent GABAergic gain modulation. Local application of the GABA(A) receptor antagonist bicuculline methochloride amplifies the underlying discharge frequency (F(n)) patterns mediated by
M Goel et al.
Folia microbiologica, 48(3), 363-368 (2003-07-26)
(+/-)-alpha-Hydrastine and (+/-)-beta-hydrastine were isolated from Corydalis longipes; both exhibited considerable efficacy against spore germination of some saprophytic and phytopathogenic fungi. While (+/-)-alpha-hydrastine was effective against most of the fungi, Helminthosporium echinoclova was least affected even at the highest dose
Shou Yu Yin et al.
Biological & pharmaceutical bulletin, 30(8), 1547-1550 (2007-08-02)
(1R,9S)-beta-hydrastine (BHS) decreases the basal intracellular Ca(2+) concentration ([Ca(2+)](i)) in PC12 cells.(5) This study examined the effects of (1R,9S)-BHS on [Ca(2+)](i) in PC12 cells. (1R,9S)-BHS at 10-100 microM in combination with a high extracellular K+ level (56 mM) inhibited the
Alex D Bain et al.
Magnetic resonance in chemistry : MRC, 48(8), 630-641 (2010-07-01)
The INADEQUATE experiment can provide unequalled, detailed information about the carbon skeleton of an organic molecule. However, it also has the reputation of requiring unreasonable amounts of sample. Modern spectrometers and probes have mitigated this problem, and it is now
David J Edwards et al.
Journal of the American Pharmacists Association : JAPhA, 43(3), 419-423 (2003-07-03)
To determine the concentration of hydrastine and berberine, the primary alkaloids in herbal products containing goldenseal. Descriptive comparison of 20 products purchased at local pharmacies or health food stores; 17 products were labeled as containing goldenseal root and 3 products
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