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Y0001427

Carvedilol

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):
1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol, BM-14190
Empirical Formula (Hill Notation):
C24H26N2O4
CAS Number:
72956-09-3
Molecular Weight:
406.47
MDL number:
MFCD00864692
PubChem Substance ID:
329831422
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

carvedilol

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OC(COC1=CC=CC2=C1C3=C(C=CC=C3)N2)CNCCOC4=CC=CC=C4OC

InChI

1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3

InChI key

OGHNVEJMJSYVRP-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRB1(153) , ADRB2(154) , ADRB3(155)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Carvedilol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Cavedilol is a non-selective β-adrenergic blocker with α1 blocking activity. Carvedilol is used specifically for the treatment of heart failure and high blood pressure. It has been shown to improve left ventricular ejection fraction and may reduce mortality.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

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Description
Pricing

1096622

Carvedilol, United States Pharmacopeia (USP) Reference Standard

Y0000103

Carvedilol impurity C, European Pharmacopoeia (EP) Reference Standard

Y0001426

Carvedilol for system suitability, European Pharmacopoeia (EP) Reference Standard

1096644

Carvedilol Related Compound B, United States Pharmacopeia (USP) Reference Standard

1096677

Carvedilol Related Compound E, United States Pharmacopeia (USP) Reference Standard

1096633

Carvedilol Related Compound A, United States Pharmacopeia (USP) Reference Standard

1096666

Carvedilol Related Compound D, United States Pharmacopeia (USP) Reference Standard

1096655

Carvedilol Related Compound C, United States Pharmacopeia (USP) Reference Standard

1096688

Carvedilol System Suitability Mixture, United States Pharmacopeia (USP) Reference Standard

PHR2434

Carvedilol Related Compound D, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2435

Carvedilol Related Compound E, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2952

Carvedilol Related Compound B, pharmaceutical secondary standard, certified reference material

PHR2953

Carvedilol Related Compound C, pharmaceutical secondary standard, certified reference material

Pictograms

Environment
GHS09

Hazard Statements

H411

Precautionary Statements

P273 - P391 - P501

Hazard Classifications

Aquatic Chronic 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Information

监管及禁止进口产品

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Randall P Sharp et al.
The Annals of pharmacotherapy, 42(4), 564-571 (2008-03-28)
To examine the evidence regarding the impact of carvedilol on the serum lipid profile. Searches in MEDLINE and International Pharmaceutical Abstracts (1966-December 2007) were conducted. Search terms included carvedilol, cholesterol, lipids, hyperlipidemia, and beta-blockers. Published studies and case reports that
Dhiraj Tripathi et al.
European journal of gastroenterology & hepatology, 22(8), 905-911 (2010-01-23)
Carvedilol is a potent noncardioselective beta-blocker, with weak vasodilating properties because of alpha 1 blockade. A reduction in both intrahepatic and portocollateral resistance contribute to enhanced effects on portal pressure. There are 10 published hemodynamic studies involving 168 patients investigating
Adrian J Stanley et al.
Journal of hepatology, 61(5), 1014-1019 (2014-06-24)
Rebleeding after an initial oesophageal variceal haemorrhage remains a significant problem despite therapy with band ligation, non-selective β-blockers or a combination of these. Carvedilol is a vasodilating non-selective β-blocker with alpha-1 receptor and calcium channel antagonism. A recent study has
Carol Chen-Scarabelli et al.
American journal of cardiovascular drugs : drugs, devices, and other interventions, 12(6), 391-401 (2012-10-16)
β-Adrenergic receptor antagonists (β-blockers) have been recognized for their cardioprotective properties, prompting use of these pharmacologic agents to become more mainstream in acute myocardial infarction (AMI) and congestive heart failure (CHF). Despite their popularity as a class, the ability to
James J DiNicolantonio et al.
The American journal of cardiology, 113(3), 565-569 (2013-12-18)
A systematic review and meta-analysis was performed to evaluate the effects of carvedilol versus metoprolol on the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting in randomized controlled trials. Ovid MEDLINE, PubMed, CENTRAL, and Excepta Medica
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