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Sigma-Aldrich

Sodium phosphate tribasic dodecahydrate

≥98%

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Synonym(s):
TSP, Trisodium phosphate (tert) dodecahydrate, Trisodium phosphate dodecahydrate
Linear Formula:
Na3PO4 · 12H2O
CAS Number:
10101-89-0
Molecular Weight:
380.12
EC Number:
231-509-8
MDL number:
MFCD00149198
PubChem Substance ID:
57646747
NACRES:
NA.25

Quality Level

200

Assay

≥98%

form

crystalline

impurities

≤0.001% heavy metals (as Pb)
≤2.5% free alkali (as NaOH)

solubility

boiling water: soluble 1 part
water: soluble 3.5 parts
alcohol: insoluble

density

1.62 g/mL at 25 °C

anion traces

chloride (Cl-): ≤0.01%
sulfate (SO42-): ≤0.01%

cation traces

As: ≤1 mg/kg
Fe: ≤10 mg/kg

SMILES string

O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+].[O-]P([O-])([O-])=O

InChI

1S/3Na.H3O4P.12H2O/c;;;1-5(2,3)4;;;;;;;;;;;;/h;;;(H3,1,2,3,4);12*1H2/q3*+1;;;;;;;;;;;;;/p-3

InChI key

ASTWEMOBIXQPPV-UHFFFAOYSA-K

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Application

Sodium phosphate tribasic dodecahydrate was used to prepare buffer solution used in the analysis of pyronaridine in human whole blood and plasma by using high-performance liquid chromatography.

Biochem/physiol Actions

Sodium phosphate tribasic also referred to as Trisodium phosphate or TSP is a widely used cleaning agent. Trisodium phosphate disrupts cytoplasmic as well as outer membranes of Salmonella enterica cells and hence prevents the spread of bacteria. Further, it is corrosion inhibitor for iron and inhibits the rate of the anodic iron dissolution reaction in unbuffered solutions.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315 - H319 - H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Y C Chen et al.
Journal of chromatography. B, Biomedical sciences and applications, 752(1), 39-46 (2001-03-20)
An improved high-performance liquid chromatography method using a diisopropyl-C14 reversed-phase column (Zorbax Bonus-RP column) and a liquid-liquid extraction technique with UV detection is presented for the analysis of pyronaridine in human whole blood and plasma. Tribasic phosphate buffer (50 mM
Behaviour of sodium silicate and sodium phosphate (tribasic) as corrosion inhibitors for iron.
R. D. Armstrong
J. Appl. Electrochem., 24, 1244-1248 (1994)
Balamurugan Sampathkumar et al.
Applied and environmental microbiology, 69(1), 122-129 (2003-01-07)
Trisodium phosphate (TSP) is now widely used during the processing of poultry and red meats, but the mechanism whereby it inactivates gram-negative bacteria such Salmonella spp. remains unclear. Thus, Salmonella enterica serovar Enteritidis (ATCC 4931) cells were treated with different
Santosh Lamichhane et al.
Analytical chemistry, 87(12), 5930-5937 (2015-05-20)
Metabolomic analyses of fecal material are gaining increasing attention because the gut microbial ecology and activity have an impact on the human phenotype and regulate host metabolism. Sample preparation is a crucial step, and in this study, we recommend a
Joshua C Cheng et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(26), 9689-9700 (2015-07-03)
Temporal summation of pain (TSP), the perception of increasingly greater pain evoked by repetitive noxious stimuli, is highly variable between individuals. Individuals with facilitated pain processing and/or reduced pain-modulatory capabilities are regarded as pronociceptive, whereas individuals with reduced pain processing
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