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Merck
CN

137252

BIS-TRIS hydrochloride

EMPROVE® EVOLVE

Synonym(s):

BIS-TRIS hydrochloride, 2,2-Bis(hydroxymethyl)-2,2′,2″-nitrilotriethanol, 2-Bis(2-hydroxyethyl)amino-2-(hydroxymethyl)-1,3-propanediol, Bis(2-hydroxyethyl)aminotris(hydroxymethyl)methane

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About This Item

Empirical Formula (Hill Notation):
C8H19NO5 · HCl
CAS Number:
124763-51-5
Molecular Weight:
245.70
UNSPSC Code:
12161705
MDL number:
MFCD00171252

Key Documents

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Product Name

BIS-TRIS hydrochloride, EMPROVE® EVOLVE

InChI key

VEYRVLHAMHQVTC-UHFFFAOYSA-N

InChI

1S/C8H19NO5.ClH/c10-3-1-9(2-4-11)8(5-12,6-13)7-14;/h10-14H,1-7H2;1H

SMILES string

Cl.OCCN(CCO)C(CO)(CO)CO

biological source

synthetic

product line

EMPROVE® EVOLVE

assay

≥99%

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, heavy metals, trace metals, residual solvents, tested

pH

5.8-7.2

useful pH range

5.8-7.2

 

6.5

pKa 

6.5

suitability

suitable for manufacturing use

application(s)

pharmaceutical (small molecule)

foreign activity

Cytotoxicity, DNase, NICKase, RNase, and Protease; tested

storage temp.

2-30°C

Quality Level

400

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Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

Application

Bis Tris HCl is a commonly used biological buffer for very broad usage in biological systems such as diagnostics, electrophoresis and protein based bioprocessing. The pKa of Bis Tris is 6.36, which makes it a good candidate for biological-based formulations.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
CDBG8876
CDBG8491
CDBG8490
CDBG8489
CDBG8420

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