137269
BIS-TRIS propane
EMPROVE® EVOLVE
Synonym(s):
BIS-TRIS propane, 1,3-Bis[tris(hydroxymethyl)methylamino]propane
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About This Item
Linear Formula:
CH2[CH2NHC(CH2OH)3]2
CAS Number:
Molecular Weight:
282.33
UNSPSC Code:
12161705
Beilstein/REAXYS Number:
1786109
MDL number:
biological source
synthetic
Quality Level
product line
EMPROVE® EVOLVE
form
powder
technique(s)
cell culture | mammalian: suitable
pH
6.3-9.5
useful pH range
6.3-9.5
pKa (25 °C)
(1) 6.8, (2) 9.0
pKa
(1) 6.8, (2) 9.0
mp
164-165 °C (lit.)
suitability
suitable for manufacturing use
foreign activity
Cytotoxicity, DNase, NICKase, RNase, and Protease; tested
storage temp.
2-30°C
SMILES string
OCC(CO)(CO)NCCCNC(CO)(CO)CO
InChI
1S/C11H26N2O6/c14-4-10(5-15,6-16)12-2-1-3-13-11(7-17,8-18)9-19/h12-19H,1-9H2
InChI key
HHKZCCWKTZRCCL-UHFFFAOYSA-N
Application
Bis Tris Propane is a unique biological buffer also referred to as a “Universal” buffer, which means the buffer capacity covers a wide range. Bis Tris Propane has two pKas of 6.3 and 9.5, which expands the buffering range from 5.0-10.5-making this a versatile buffer for biological systems. Bis Tris Propane is considered to be non-toxic to culture cell lines and provides high-solution clarity.A review of DNA polymerase techniques lists bis tris propane as a suitable buffer for PCR methods as a universal buffer pH gradient is employed.
Legal Information
Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| PH016042-250MG | 04061831282450 |
| 1372691000 | 04065267204802 |
| 1372699010 | 04065267204826 |
| 1372690003 | 04065267204789 |
| 1372695000 | 04065267204819 |
| 1372690100 | 04065267204796 |