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Merck
CN

137279

L-Arginine

EMPROVE® EXPERT, EP, USP

Synonym(s):

(S)-2-Amino-5-guanidinopentanoic acid

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About This Item

Linear Formula:
H2NC(=NH)NH(CH2)3CH(NH2)CO2H
CAS Number:
74-79-3
Molecular Weight:
174.20
UNSPSC Code:
12352209
NACRES:
NA.26
eCl@ss:
32160406
MDL number:
MFCD00002635
Beilstein/REAXYS Number:
1725413

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InChI

1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1

SMILES string

N[C@@H](CCCNC(N)=N)C(O)=O

InChI key

ODKSFYDXXFIFQN-BYPYZUCNSA-N

biological source

non-animal source

agency

EP, USP

product line

EMPROVE® EXPERT

assay

>98.5%

form

crystalline powder

technique(s)

cell culture | mammalian: suitable

mp

222 °C (dec.) (lit.)

solubility

H2O: 100 mg/mL

suitability

suitable for manufacturing use

application(s)

pharmaceutical (small molecule)

Quality Level

500

Gene Information

human ... NOS1(4842), NOS2(4843)
rat ... Ppm1a(24666)

impurities

endotoxin, residual solvents

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General description

Our SAFC® portfolio of high-quality products for biopharmaceutical processing withstands strict quality control procedures and is produced according to MQ-500 requirements as defined by the M-Clarity program.

M-Clarity Program

As part of our Emprove® Program, our raw materials are offered with Emprove® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.
To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.

Application

L-Arginine is a non-essential amino acid. It is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies. L-Arginine monohydrochloride is a modified version of L-Arginine with improved solubility.

Biochem/physiol Actions

Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
CDBG8682
CDBG8681
CDBG8680
CDBG8674
CDBG8678

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