A123
R-(+)-p-Aminoglutethimide (+)-tartrate salt
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About This Item
Empirical Formula (Hill Notation):
C13H16N2O2 · C4H6O6
CAS Number:
Molecular Weight:
382.37
PubChem Substance ID:
UNSPSC Code:
12352202
assay
99.4% (HPLC)
mp
124-127 °C
shipped in
ambient
SMILES string
O[C@H]([C@@H](O)C(O)=O)C(O)=O.CC[C@@]1(CCC(=O)NC1=O)c2ccc(N)cc2
InChI
1S/C13H16N2O2.C4H6O6/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9;5-1(3(7)8)2(6)4(9)10/h3-6H,2,7-8,14H2,1H3,(H,15,16,17);1-2,5-6H,(H,7,8)(H,9,10)/t13-;1-,2-/m11/s1
InChI key
DQUXPVVSVXIQNE-IMXLTCNTSA-N
Biochem/physiol Actions
Inhibitor of aromatases involved in conversion of androgens to estrogens, and thus useful in chemotherapy of hormone-sensitive tumors (e.g., breast cancer). Also inhibits corticosteroid biosynthesis, termed a "medical adrenalectomy."
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Martina Dieber-Rotheneder et al.
Journal of the Society for Gynecologic Investigation, 13(6), 435-441 (2006-08-02)
This study tested the hypothesis that the endothelin (ET)/ET receptor (ETR) system in biologic fluids and in the human placenta is altered in delayed miscarriages as compared to apparently normal early pregnancies (reference group). Immunoreactive ET (irET) concentrations were measured
E J Sanford et al.
The Journal of urology, 115(2), 170-174 (1976-02-01)
Complete adrenal suppression with aminoglutethimide has been accomplished in 7 patients with progressive stage D carcinoma of the prostate who had become refractory to orchiectomy and the administration of exogenous estrogens. A favorable response was noted in 3 patients. These
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