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Merck
CN

A2836

Ansamitocin P-3 from Actinosynnema pretiosum

≥90% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C32H43ClN2O9
CAS Number:
66584-72-3
Molecular Weight:
635.14
NACRES:
NA.32
PubChem Substance ID:
24890696
UNSPSC Code:
12352202
MDL number:
MFCD00274586
Form:
powder
Assay:
≥90% (HPLC)

Key Documents

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Quality Level

200

assay

≥90% (HPLC)

form

powder

storage temp.

2-8°C

SMILES string

CO[C@@H]1\C=C\C=C(C)\Cc2cc(OC)c(Cl)c(c2)N(C)C(=O)C[C@H](OC(=O)C(C)C)[C@]3(C)O[C@@H]3[C@H](C)[C@@H]4C[C@@]1(O)NC(=O)O4

InChI

1S/C32H43ClN2O9/c1-17(2)29(37)43-25-15-26(36)35(6)21-13-20(14-22(40-7)27(21)33)12-18(3)10-9-11-24(41-8)32(39)16-23(42-30(38)34-32)19(4)28-31(25,5)44-28/h9-11,13-14,17,19,23-25,28,39H,12,15-16H2,1-8H3,(H,34,38)/b11-9+,18-10+/t19-,23+,24-,25+,28-,31+,32+/m1/s1

InChI key

OPQNCARIZFLNLF-KUDLRRJMSA-N

Biochem/physiol Actions

Fungal metabolite with antineoplastic, antimitotic activity. Binds to tubulin and inhibits vinblastine-induced spiral formation.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLCG1549
SLBS0227V
SLBQ5759V
SLBN9774V
SLBJ2882V

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Carl E Snipes et al.
Journal of natural products, 70(10), 1578-1581 (2007-09-26)
The ansacarbamitocins are a new family of maytansinoids that are unusually substituted with a glucose subunit and two carbamate functional groups and exhibit modest activity against some agricultural fungal disease organisms. Ansacarbamitocins A-F ( 1- 6) all consist of the
Yuqin Yao et al.
Journal of separation science, 33(9), 1331-1337 (2010-03-18)
Ansamitocin P-3 is a potent anti-tumor maytansinoid found in Actinosynnema pretiosum. However, due to the complexity of the fermentation broth of Actinomycete, how to effectively separate ansamitocin P-3 is still a challenge. In this study, both analytical and preparative high-performance
Tobias Knobloch et al.
Chembiochem : a European journal of chemical biology, 12(4), 540-547 (2012-01-13)
New ansamitocin derivatives were prepared by feeding aminobenzoic acid derivatives to cultures of Actinosynnema pretiosum HGF073, a mutant strain blocked in the biosynthesis of the required 3-amino-5-hydroxybenzoic acid (AHBA) starter unit. Use of several aminobenzoic acids as precursors led to
Yongliang Jia et al.
Bioresource technology, 102(21), 10147-10150 (2011-09-13)
The effect of divalent metal ions (i.e., Mn(2+), Mg(2+), Zn(2+), Cu(2+), and Co(2+)) on the production of anticancer ansamitocin P-3 (AP-3) by submerged cultures of Actinosynnema pretiosum in medium containing agro-industrial residues was investigated, and Mg(2+) was found to be
Nathaniel L Segraves et al.
Magnetic resonance in chemistry : MRC, 50(3), 256-259 (2012-03-01)
During impurity analysis of maytansinol (2), produced from the reduction of ansamitocin P-3 (AP-3, 1), a surprisingly stable acyclic hemiacetal (4) was isolated. A combination of 1D and 2D NMR experiments, along with liquid chromatography-mass spectrometry data was used to
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Global Trade Item Number

SKUGTIN
A2836-1MG04061833359792

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