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A5508

Adenosine 5′-phosphosulfate sodium salt

Name: Adenosine 5&#8242;-phosphosulfate sodium salt
Brand: SIGMA

≥85%, synthetic (organic), powder

Synonym(s):

APS

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₄N₅O₁₀PS

CAS Number:

102029-95-8

Molecular Weight:

427.28

UNSPSC Code:

41106305

PubChem Substance ID:

24890980

NACRES:

NA.51

MDL number:

MFCD00057011

Assay:

≥85%

Biological source:

synthetic (organic)

Form:

powder

Solubility:

water: 50 mg/mL, clear to hazy, colorless to light yellow

Storage temp.:

−20°C

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Product Name

Adenosine 5′-phosphosulfate sodium salt, ≥85%

biological source

synthetic (organic)

Quality Level

200

assay

≥85%

form

powder

solubility

water: 50 mg/mL, clear to hazy, colorless to light yellow

documentation

see Safety & Documentation for available documents

food allergen

no known allergens

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OS(O)(=O)=O)C(O)C3O

InChI

1S/C10H14N5O10PS.Na.H/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22);;

InChI key

KLZADYTZAADWRW-UHFFFAOYSA-N

Application

Adenosine 5′-phosphosulfate sodium salt has been used in enzyme-linked bioluminescence assay for adenosine triphosphate (ATP) and pyrophosphate quantification.

Biochem/physiol Actions

Adenosine 5′ phosphosulfate (APS) is used as a substrate of adenosine triphosphate (ATP) sulfurylase to complete a PP(i)-recycling loop for exponential ATP amplification in firefly luciferase ATP luminescence assay and other pyrophosphate regeneration-dependent detection assays.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000539708

0000508607

0000482767

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Defective extracellular pyrophosphate metabolism promotes vascular calcification in a mouse model of Hutchinson-Gilford progeria syndrome that is ameliorated on pyrophosphate treatment

Villa BR, et al.

Circulation, 127(24), 2442-2451 (2013)

Novel bioluminescent assay of alkaline phosphatase using adenosine-3?-phosphate-5?-phosphosulfate as substrate and the luciferin-luciferase reaction and its application

Arakawa H, et al.

Analytical biochemistry, 314(2), 206-211 (2003)

Nonlinear optical microscopy is a novel tool for the analysis of cutaneous alterations in pseudoxanthoma elasticum.

Norbert Kiss et al.

Lasers in medical science, 35(8), 1821-1830 (2020-05-07)

Pseudoxanthoma elasticum (PXE, OMIM 264800) is a rare autosomal recessive disorder with ectopic mineralization and fragmentation of elastin fibers. It is caused by mutations of the ABCC6 gene that leads to decreased serum levels of inorganic pyrophosphate (PPi) anti-mineralization factor.

Characterization of Entamoeba histolytica adenosine 5'-phosphosulfate (APS) kinase; validation as a target and provision of leads for the development of new drugs against amoebiasis.

Fumika Mi-Ichi et al.

PLoS neglected tropical diseases, 13(8), e0007633-e0007633 (2019-08-20)

Amoebiasis, caused by Entamoeba histolytica infection, is a global public health problem. However, available drugs to treat amoebiasis are currently limited, and no effective vaccine exists. Therefore, development of new preventive measures against amoebiasis is urgently needed. Here, to develop

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.

Momoko Horikoshi et al.

PLoS genetics, 11(7), e1005230-e1005230 (2015-07-02)

Reference panels from the 1000 Genomes (1000G) Project Consortium provide near complete coverage of common and low-frequency genetic variation with minor allele frequency ≥0.5% across European ancestry populations. Within the European Network for Genetic and Genomic Epidemiology (ENGAGE) Consortium, we

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Global Trade Item Number

SKU	GTIN
A5508-5MG	04061833001943
A5508-50MG	04061833001936

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