A9295
4-Androsten-4-ol-3,17-dione acetate
Synonym(s):
4-Acetoxy-4-androstene-3,17-dione
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About This Item
Empirical Formula (Hill Notation):
C21H28O4
CAS Number:
Molecular Weight:
344.44
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
Form:
solid
form
solid
shipped in
ambient
storage temp.
2-8°C
SMILES string
CC(=O)OC1=C2CC[C@H]3[C@@H]4CCC(=O)[C@@]4(C)CC[C@@H]3[C@@]2(C)CCC1=O
InChI
1S/C21H28O4/c1-12(22)25-19-16-5-4-13-14-6-7-18(24)21(14,3)10-8-15(13)20(16,2)11-9-17(19)23/h13-15H,4-11H2,1-3H3/t13-,14-,15-,20+,21-/m0/s1
InChI key
LRXSFNGKRCOHRS-VMRCMBGLSA-N
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Recent advances in studies on estrogen biosynthesis.
A M Brodie
Journal of endocrinological investigation, 2(4), 445-460 (1979-10-01)
A M Brodie et al.
Cancer research, 42(8 Suppl), 3360s-3364s (1982-08-01)
Aromatase inhibitor, 4-hydroxyandrostene-3,17-dione (4-OHA), is a highly effective treatment in rats with 7,12-dimethylbenz(a) anthracene-induced hormone-dependent mammary tumors. Over 90% of tumors regress to less than one-half of their original size, and a high proportion regress completely. Treatment of rats with
A M Brodie et al.
Steroids, 38(6), 693-702 (1981-12-01)
4-Hydroxy-4-androstene-3,17-dione (4-OHA) and 4-acetoxy-4-androstene-3,17-dione (4-AcA), in addition to being competitive inhibitors of aromatase, cause time-dependent, irreversible, loss of enzyme activity in both human placental and rat ovarian microsomes. In vivo, treatment of rats with 4-OHA also causes loss of ovarian