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B016

Benoxathian hydrochloride

solid

Synonym(s):

2-[[[2-(2,6-Dimethoxyphenoxy)ethyl]-amino]-methyl]-1,4-benzoxathian hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H23NO4S · HCl
CAS Number:
92642-97-2
Molecular Weight:
397.92
NACRES:
NA.77
PubChem Substance ID:
24277758
UNSPSC Code:
12352202
MDL number:
MFCD00055188
Form:
solid
Quality level:
100
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form

solid

Quality Level

100

color

white

solubility

H2O: soluble (Aqueous solutions may be stored for several weeks at -20 °C.), ethanol: soluble, isopropanol: soluble

SMILES string

Cl.COc1cccc(OC)c1OCCNCC2CSc3ccccc3O2

InChI

1S/C19H23NO4S.ClH/c1-21-16-7-5-8-17(22-2)19(16)23-11-10-20-12-14-13-25-18-9-4-3-6-15(18)24-14;/h3-9,14,20H,10-13H2,1-2H3;1H

InChI key

OWRADFDDJVNMGL-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Biochem/physiol Actions

Selective α1-adrenoceptor antagonist.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
117H46572
117H4657

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A J Douglas et al.
Journal of neuroendocrinology, 17(1), 40-48 (2005-02-22)
We investigated whether changes in noradrenaline neurotransmission in the hypothalamus could explain the hyporesponsiveness of the hypothalamic-pituitary-adrenal (HPA) axis in late pregnancy. Noradrenaline release within the hypothalamic paraventricular nucleus in response to swim stress, as estimated by microdialysis and high-performance
Cauveh Erami et al.
American journal of physiology. Heart and circulatory physiology, 283(4), H1577-H1587 (2002-09-18)
Previous studies suggesting that norepinephrine is directly trophic for the vascular wall have been confounded by concomitant hemodynamic disturbances. Herein, a microcatheter connected to an osmotic minipump was implanted adjacent to the rat carotid for 2-wk perivascular suffusion of agents
Y Madrero et al.
British journal of pharmacology, 119(8), 1563-1568 (1996-12-01)
1. The selectivity of action of boldine and the related aporphine alkaloids, predicentrine (9-O-methylboldine) and glaucine (2,9-O-dimethylboldine) and alpha 1-adrenoceptor subtypes was studied by examining [3H]-prazosin competition binding in rat cerebral cortex. WB 4101 and benoxathian were used as selective
G J Marek et al.
European journal of pharmacology, 305(1-3), 95-100 (1996-06-03)
Pharmacological techniques have defined the existence of two different alpha 1-adrenoceptors, the alpha 1A- and alpha 1B-adrenoceptor subtypes and both of these receptors have been cloned in addition to a cloned alpha 1d-adrenoceptor. A subpopulation of interneurons in layer III
A Douglas et al.
Endocrinology, 142(2), 633-644 (2001-02-13)
Oxytocin secretion is important for the normal progress of parturition in the rat. We tested the hypotheses that contractions of the uterus before pup delivery activate oxytocin neurons, and that they do so via a noradrenergic projection. In anesthetized 22-day
View All Related Papers

Global Trade Item Number

SKUGTIN
B016-25MG04061832088792
B016-10MG04061832088785

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