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Merck
CN

B0936

BRL 50481

≥98% (HPLC), solid

Synonym(s):

5-Nitro-2,N,N-trimethylbenzenesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C9H12N2O4S
CAS Number:
433695-36-4
Molecular Weight:
244.27
NACRES:
NA.77
PubChem Substance ID:
24277757
UNSPSC Code:
12352200
MDL number:
MFCD03039912
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100

Key Documents

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Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: >10 mg/mL, H2O: insoluble

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

CN(C)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O

InChI

1S/C9H12N2O4S/c1-7-4-5-8(11(12)13)6-9(7)16(14,15)10(2)3/h4-6H,1-3H3

InChI key

IFIUFCJFLGCQPH-UHFFFAOYSA-N

Gene Information

human ... PDE7A(5150), PDE7B(27115)

Related Categories

Biochem/physiol Actions

BRL 50481 is a potent and selective PDE7 inhibitor (IC50 = 260 nM).

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from GlaxoSmithKline

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000143303
0000143304
0000140512
0000062285
0000062286

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Lucie Jiraskova et al.
Molecular pharmaceutics, 15(7), 2732-2741 (2018-05-22)
Equilibrative ( SLC29A) and concentrative ( SLC28A) nucleoside transporters contribute to proper placental development and mediate uptake of nucleosides/nucleoside-derived drugs. We analyzed placental expression of SLC28A mRNA during gestation. Moreover, we studied in choriocarcinoma-derived BeWo cells whether SLC29A and SLC28A
Maike Monzel et al.
FEBS letters, 588(18), 3469-3474 (2014-08-17)
The degradation and biological role of the cyclic pyrimidine nucleotide cCMP is largely elusive. We investigated nucleoside 3',5'-cyclic monophosphate (cNMP) specificity of six different recombinant phosphodiesterases (PDEs) by using a highly-sensitive HPLC-MS/MS detection method. PDE7A1 was the only enzyme that

Articles

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

Global Trade Item Number

SKUGTIN
B0936-5MG04061832977072
B0936-25MG04061832977065

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