B107
L-BMAA hydrochloride
≥97% (NMR), neurotoxin, powder
Synonym(s):
S(+)-2-Amino-3-(methylamino)propionic acid hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C4H10N2O2 · HCl
CAS Number:
Molecular Weight:
154.60
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
MDL number:
Product Name
L-BMAA hydrochloride, ≥97% (NMR), powder
Quality Level
assay
≥97% (NMR)
form
powder
optical activity
[α]/D +21 to +31°, c = 0.5 M in 0.1 M HCl(lit.)
storage condition
desiccated
color
white to beige
solubility
H2O: soluble (solutions may be stored for several days at 4 °C)
storage temp.
−20°C
SMILES string
Cl.CNC[C@H](N)C(O)=O
InChI
1S/C4H10N2O2.ClH/c1-6-2-3(5)4(7)8;/h3,6H,2,5H2,1H3,(H,7,8);1H/t3-;/m0./s1
InChI key
VDXYGASOGLSIDM-DFWYDOINSA-N
General description
L-BMAA hydrochloride/β-N-methylamino-l-alanine (BMAA) is a cyanobacterial neurotoxin.
Application
L-BMAA hydrochloride has been used as a standard to compare all the samples in the analysis of β-N-methylamino-l-alanine (BMAA) isomers in desert crust material. It has also been used as an additive with f/2+Si medium to treat the cells of Phaeodactylum tricornutum and Thalassiosira weissflogii to study its effect on them.
Biochem/physiol Actions
L-BMAA hydrochloride helps to block the addition of heparan sulfate to glypican-1. It possesses unusual glutamate receptor binding properties. It may cause amyotrophic lateral sclerosis/Lou Gehrig′s disease.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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David A Davis et al.
Journal of neuropathology and experimental neurology, 79(4), 393-406 (2020-02-23)
The early neuropathological features of amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) are protein aggregates in motor neurons and microglial activation. Similar pathology characterizes Guamanian ALS/Parkinsonism dementia complex, which may be triggered by the cyanotoxin β-N-methylamino-l-alanine (BMAA). We report here the
Olga A Koksharova et al.
Toxins, 12(6) (2020-06-10)
All cyanobacteria produce a neurotoxic non-protein amino acid β-N-methylamino-L-alanine (BMAA). However, the biological function of BMAA in the regulation of cyanobacteria metabolism still remains undetermined. It is known that BMAA suppresses the formation of heterocysts in diazotrophic cyanobacteria under nitrogen
Neurotoxic amino acids and their isomers in desert environments
Metcalf JS, et al.
Journal of arid environments, 140-144 (2015)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B107-10MG | 04061833420515 |
| B107-50MG | 04061833420553 |