B4750
Nα-Benzoyl-DL-arginine β-naphthylamide hydrochloride
trypsin substrate
Synonym(s):
BANA, Nα-Benzoyl-DL-arginine-2-naphthylamide hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C23H25N5O2 · HCl
CAS Number:
Molecular Weight:
439.94
UNSPSC Code:
12352204
NACRES:
NA.32
PubChem Substance ID:
EC Number:
213-015-4
Beilstein/REAXYS Number:
3823291
MDL number:
Quality Level
assay
≥98% (TLC)
form
powder
solubility
DMF: 50 mg/mL, clear, colorless to faintly yellow
storage temp.
2-8°C
SMILES string
Cl[H].NC(=N)NCCCC(NC(=O)c1ccccc1)C(=O)Nc2ccc3ccccc3c2
InChI
1S/C23H25N5O2.ClH/c24-23(25)26-14-6-11-20(28-21(29)17-8-2-1-3-9-17)22(30)27-19-13-12-16-7-4-5-10-18(16)15-19;/h1-5,7-10,12-13,15,20H,6,11,14H2,(H,27,30)(H,28,29)(H4,24,25,26);1H
InChI key
BNGRKDJZQIGWQF-UHFFFAOYSA-N
General description
A chromogenic substrate for trypsin.
Application
Nα-Benzoyl-DL-arginine β-naphthylamide hydrochloride has been used as a substrate in the BANA test to evaluate the inhibitory activity of stefin. It has also been used as a substrate for the determination of Ki values of inhibitors toward trypsin.
Biochem/physiol Actions
Nα-Benzoyl-DL-arginine β-naphthylamide hydrochloride (BANA) helps to determine the activities of cathepsin B and papain. BANA test is also useful in identifying the number of periodontal sites with periodontal pathogens. Presence of volatile sulfur compounds (VSCs), synthesized by oral bacteria in dental plaque or tongue coating can be colorimetrically confirmed by their ability to hydrolyze N-benzoyl-DL-arginine-2-naphthylamide.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Mervyn Sydney Turton et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 22(8), 740-746 (2017-06-01)
Although the association between periodontal disease (PD) and adverse pregnancy outcomes has gained recognition amongst antenatal healthcare workers, not much has changed in practice to address it. This prospective study tested the hypothesis that BANA (N-benzoyl-DL-arginine-2-naphthylamide), a diagnostic test for
Erich Loza Telleria et al.
PloS one, 5(5), e10697-e10697 (2010-05-27)
Midgut enzymatic activity is one of the obstacles that Leishmania must surpass to succeed in establishing infection. Trypsins are abundant digestive enzymes in most insects. We have previously described two trypsin cDNAs of L. longipalpis: one (Lltryp1) with a bloodmeal
Ravinder Kaur et al.
Bioorganic chemistry, 104, 104174-104174 (2020-09-16)
Cathepsins have emerged as important targets in various tissues degenerative disorders due to their involvement in degradation of extracellular matrices and endogenous protein turnover. Elevated cathepsins levels vis-à-vis decreased concentration of endogenous inhibitors has been reported at different diseased sites.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B4750-1G | 04061833433447 |
| B4750-500MG | 04061832921334 |
| B4750-5G | 04061832921341 |