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B5402

Bromazepam

Name: Bromazepam
Brand: SIGMA

drug standard, 1.0 mg/mL in methanol

Synonym(s):

7-Bromo-5-(2-pyridyl)-3H-1,4-benzodiaxepin-2(1H)-one

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₀BrN₃O

CAS Number:

1812-30-2

Molecular Weight:

316.15

UNSPSC Code:

41116107

PubChem Substance ID:

329773257

EC Number:

200-659-6

MDL number:

MFCD00057902

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grade

drug standard

assay

≥98%

drug control

USDEA Schedule IV; Home Office Schedule 4.1; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet, kontrollierte Droge in Deutschland

concentration

1.0 mg/mL in methanol

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

single component solution

storage temp.

2-8°C

SMILES string

O=C(CN=C1C2=CC=CC=N2)NC3=C1C=C(Br)C=C3

InChI

1S/C14H10BrN3O/c15-9-4-5-11-10(7-9)14(17-8-13(19)18-11)12-3-1-2-6-16-12/h1-7H,8H2,(H,18,19)

InChI key

VMIYHDSEFNYJSL-UHFFFAOYSA-N

Gene Information

human ... GABRA2(2555)

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

pictograms

GHS02,GHS06,GHS08

signalword

Danger

hcodes

H225,H301,H311,H331,H370

pcodes

P210 - P260 - P280 - P301 + P310 - P311

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

51.8 °F - closed cup

flash_point_c

11 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves

Regulatory Information

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Detection of amitriptyline, nortriptyline and bromazepam in liver, CSF and hair in the homicidal poisoning of a one-month-old girl autopsied 8 months after death.

Yvan Gaillard et al.

Forensic science international, 207(1-3), e16-e18 (2011-01-05)

We reported on the death by poisoning of a one-month-old baby that had followed the death of one of her sister (due to cyamemazine overdose). Exhumation of the corpse was done 8 months after burial and revealed the presence of

Spectrofluorimetric quantification of bromazepam using a highly selective optical probe based on Eu3+-bromazepam complex in pharmaceutical and serum samples.

M S Attia

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 74(4), 972-976 (2009-09-29)

A rapid, simple and sensitive spectrofluorimetric method for determination of trace amount of bromazepam is developed. In phosphate buffer of pH 7.4. The bromazepam enhance the luminescence intensity of the Eu(3+) ion in Eu(3+)-bromazepam complex at lambda(ex)=390nm. The produced luminescence

Responsiveness of sensorimotor cortex during pharmacological intervention with bromazepam.

Marlo Cunha et al.

Neuroscience letters, 448(1), 33-36 (2008-10-22)

The aim of this study was to investigate the influence of bromazepam on EEG and the motor learning process when healthy subjects were submitted to a typewriting task. We investigated bromazepam due to its abuse by various populations and its

Pharmacoepidemiological characterization of psychotropic drugs consumption using a latent class analysis.

Laura Wainstein et al.

International clinical psychopharmacology, 26(1), 54-62 (2010-10-01)

France has one of the highest recorded rates of psychotropic use of drugs compared with other European countries, especially for anxiolytics, hypnotics and antidepressants. The aim of this study was to characterize the use of three psychotropic drugs among the

Prodynorphin gene deletion increased anxiety-like behaviours, impaired the anxiolytic effect of bromazepam and altered GABAA receptor subunits gene expression in the amygdala.

Teresa Femenía et al.

Journal of psychopharmacology (Oxford, England), 25(1), 87-96 (2010-06-10)

This study evaluated the role of prodynorphin gene in the regulation of anxiety and associated molecular mechanisms. Emotional responses were assessed using the light-dark test, elevated plus maze and social interaction tests in prodynorphin knockout and wild-type mice. Corticotrophin releasing

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