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Merck
CN

C127

CNQX

≥98% (HPLC), AMPA/kainate glutamate receptor antagonist, solid

Synonym(s):

6-Cyano-7-nitroquinoxaline-2,3-dione, FG-9065

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About This Item

Empirical Formula (Hill Notation):
C9H4N4O4
CAS Number:
115066-14-3
Molecular Weight:
232.15
UNSPSC Code:
12352200
PubChem Substance ID:
24892392
NACRES:
NA.77
MDL number:
MFCD00069232
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
protect from light

Key Documents

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Product Name

CNQX, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

yellow

solubility

DMSO: >10 mg/mL, H2O: insoluble

SMILES string

[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1C#N

InChI

1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)

InChI key

RPXVIAFEQBNEAX-UHFFFAOYSA-N

Gene Information

rat ... Gria1(50592), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409)

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Application

CNQX has been used:
  • as an α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate blocker to study its effects on cytoneme formation in pluripotent embryonic stem cells (pESCs)
  • glutamate blocker to reduce the synaptic input during current-clamp recordings in central antennal lobe neurons
  • as a non-N-methyl-D-aspartate (NMDA) receptor blocker to study its effects on the heart rate in rats

Biochem/physiol Actions

Potent, competitive AMPA/kainate glutamate receptor antagonist.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000530263
0000526106
0000526106
0000530263
0000513408

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Haiyan Li et al.
Frontiers in cellular neuroscience, 11, 324-324 (2017-11-11)
Release of the major excitatory neurotransmitter glutamate by synaptic vesicle exocytosis depends on glutamate loading into synaptic vesicles by vesicular glutamate transporters (VGLUTs). The two principal isoforms, VGLUT1 and 2, exhibit a complementary pattern of expression in adult brain that
Binbin Yan et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 296(2), R299-R308 (2008-11-21)
Chronic intermittent hypoxia (CIH), as occurs in sleep apnea, impairs baroreflex-mediated reductions in heart rate (HR) and enhances HR responses to electrical stimulation of vagal efferent. We tested the hypotheses that HR responses to activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and
Sutirtha Ray et al.
Pain, 160(4), 954-964 (2019-01-03)
Paracetamol (acetaminophen, APAP) is one of the most frequently used analgesic agents worldwide. It is generally preferred over nonsteroidal anti-inflammatory drugs because it does not cause typical adverse effects resulting from the inhibition of cyclooxygenases, such as gastric ulcers. Nevertheless
Guan Hock Khoo et al.
Molecular neurobiology, 56(9), 6436-6450 (2019-03-04)
Long-term depression (LTD) of synaptic efficacy is widely regarded as a cellular basis of learning and memory. The magnitude of hippocampal CA1 LTD induced by low-frequency stimulation (LFS) declines with age, but the mechanisms involved remain poorly understood. Perineuronal nets
Emmanuelle Berret et al.
Nature communications, 8(1), 557-557 (2017-09-17)
Oligodendrocyte (OL) maturation and axon-glial communication are required for proper myelination in the developing brain. However, physiological properties of OLs remain largely uncharacterized in different brain regions. The roles of oligodendroglial voltage-activated Na+ channels (Nav) and electrical excitability in relation
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Global Trade Item Number

SKUGTIN
C127-50MG04061833467251
C127-5MG04061832089621
C127-25MG04061833467244

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