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Merck
CN

C1355

Z-Leu-Glu(O-Me)-His-Asp(O-Me) fluoromethyl ketone trifluoroacetate salt hydrate

≥90%

Synonym(s):

Z-LEHD-FMK, Z-LE(OMe)HD(OMe)-FMK

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About This Item

Empirical Formula (Hill Notation):
C32H43FN6O10 · xC2HF3O2 · yH2O
CAS Number:
210345-04-3
Molecular Weight:
690.72 (anhydrous free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329774878
MDL number:
MFCD01862609

Key Documents

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Product Name

Z-Leu-Glu(O-Me)-His-Asp(O-Me) fluoromethyl ketone trifluoroacetate salt hydrate, ≥90%

InChI

1S/C32H43FN6O10/c1-19(2)12-24(39-32(46)49-17-20-8-6-5-7-9-20)30(44)36-22(10-11-27(41)47-3)29(43)38-25(13-21-16-34-18-35-21)31(45)37-23(26(40)15-33)14-28(42)48-4/h5-9,16,18-19,22-25H,10-15,17H2,1-4H3,(H,34,35)(H,36,44)(H,37,45)(H,38,43)(H,39,46)/t22-,23-,24-,25-/m0/s1

SMILES string

COC(=O)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](CC(=O)OC)C(=O)CF

InChI key

YXRKBEPGVHOXSV-QORCZRPOSA-N

assay

≥90%

form

film

storage condition

desiccated

color

colorless to light brown

solubility

DMSO: 10 mg/mL, clear

shipped in

dry ice

storage temp.

−20°C

Application

A cell-permeable inhibitor of caspase-9, which exhibits competitive and irreversible inhibition.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
029K4604V
029K4604
057K1834
056K1373
016K1279

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