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Merck
CN

C3025

(±)-Chlorpheniramine maleate salt

≥99% (perchloric acid titration)

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About This Item

Empirical Formula (Hill Notation):
C16H19ClN2 · C4H4O4
CAS Number:
113-92-8
Molecular Weight:
390.86
NACRES:
NA.77
PubChem Substance ID:
24277767
UNSPSC Code:
12352116
EC Number:
204-037-5
MDL number:
MFCD00069225
Assay:
≥99% (perchloric acid titration)
Form:
powder
Quality level:
100

Key Documents

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Quality Level

100

assay

≥99% (perchloric acid titration)

form

powder

mp

130-135 °C (lit.)

originator

Bayer

SMILES string

CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.O=C(/C=C\C(O)=O)O

InChI

1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

DBAKFASWICGISY-BTJKTKAUSA-N

Gene Information

human ... HRH1(3269)

General description

Chlorpheniramine maleate (CPM)/(3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine is an alkylamine antihistamine.

Application

(±)-Chlorpheniramine maleate salt has been used:
  • as H1 receptor antagonist to determine the receptor function
  • to block the effect of compound 48/80 on plasma IGF-I
  • as a standard for fast sensing and determination by sequential injector coupled with potentiometer

Biochem/physiol Actions

Chlorpheniramine maleate (CPM) can prevent rhinitis and urticaria. It is used to cure several allergic conditions. This antihistamine is used in small-animal veterinary practices.
H1 Histamine receptor antagonist.

Features and Benefits

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF8336V
MKCR8192
WXBD9029V
MKCP9670
MKCM3316

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Sensing of chlorpheniramine in pharmaceutical applications by sequential injector coupled with potentiometer
Saleh TA
Journal of Pharmaceutical Analysis, 1(4), 246-250 (2011)
Endogenous histamine reduces plasma insulin-like growth factor I via H1 receptor-mediated pathway in the rat
Liao W, et al.
European Journal of Pharmacology, 374(3), 471-476 (1999)
Extracellular signal-regulated kinase (ERK) activation is required for itch sensation in the spinal cord
Zhang L, et al.
Molecular Brain, 7(1), 25-25 (2014)
V Alagarsamy et al.
European journal of medicinal chemistry, 43(11), 2331-2337 (2007-11-23)
A series of novel 1-substituted-4-(2-methylphenyl)-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones were synthesized by the cyclization of 2-hydrazino-3-(2-methylphenyl)-3H-quinazolin-4-one with various one carbon donors. The starting material 2-hydrazino-3-(2-methylphenyl)-3H-quinazolin-4-one was synthesized from 2-methyl aniline by a novel innovative route. The title compounds were tested for their in vivo
Functionalized Fe3O4 Magnetic Nanoparticle Potentiometric Detection Strategy versus Classical Potentiometric Strategy for Determination of Chlorpheniramine Maleate and Pseudoephedrine HCl
Moustafa AA, et al.
Journal of Analytical Methods in Chemistry (2019)
View All Related Papers

Global Trade Item Number

SKUGTIN
C3025-5G04061833485163
C3025-100G04061835259588
C3025-25G04061833485156

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