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C5417

Methyl β-carboline-3-carboxylate

Name: Methyl β-carboline-3-carboxylate
Brand: SIGMA

Synonym(s):

β-CCM, 9H-Pyrido[3,4-b]indole-3-carboxylic acid methyl ester

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₀N₂O₂

CAS Number:

69954-48-9

Molecular Weight:

226.23

UNSPSC Code:

12352103

MDL number:

MFCD00069265

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Properties

mp

265 °C (dec.) (lit.)

storage temp.

2-8°C

SMILES string

COC(=O)c1cc2c(cn1)[nH]c3ccccc23

Description

Biochem/physiol Actions

Benzodiazepine antagonist

Benzodiazepine inverse receptor agonist; anxiogenic; induces seizures in vivo.

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beta-Carbolines as benzodiazepine receptor ligands. 1. Synthesis and benzodiazepine receptor interaction of esters of beta-carboline-3-carboxylic acid.

K P Lippke et al.

Journal of medicinal chemistry, 26(4), 499-503 (1983-04-01)

Several esters of beta-carboline-3-carboxylic acid were synthesized and tested in respect to their affinity for the benzodiazepine receptor in bovine cortex membranes. Out of these derivatives, the methyl, ethyl, and n-propyl ester were clearly the most potent, while the n-butyl