C6770
Carbadox
Synonym(s):
3-(2-Quinoxalinylmethylene)carbazic acid methyl ester N,N′-dioxide
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About This Item
Empirical Formula (Hill Notation):
C11H10N4O4
CAS Number:
Molecular Weight:
262.22
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
229-879-0
MDL number:
form
powder
solubility
1 M NaOH: 50 mg/mL
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
SMILES string
COC(=O)N\N=C\c1cn(=O)c2ccccc2n1=O
InChI
1S/C11H10N4O4/c1-19-11(16)13-12-6-8-7-14(17)9-4-2-3-5-10(9)15(8)18/h2-7H,1H3,(H,13,16)/b12-6+
InChI key
OVGGLBAWFMIPPY-WUXMJOGZSA-N
Application
Carbadox has been used to suppress aldosterone production, to study the spread of shiga toxin-producing Escherichia coli (STEC) strains, and to compare different antimicrobial activities.
Biochem/physiol Actions
Carbadox is a quinoxaline-di-N-oxide antibiotic that is generally used in feed to swine to prevent dysentery and improve feed efficiency. It inhibits bacteria by intercalation and induction of mutations in bacterial genome.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Flam. Sol. 1
Storage Class
4.1B - Flammable solid hazardous materials
wgk
WGK 3
flash_point_f
64.4 °F - closed cup
flash_point_c
18 °C - closed cup
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G Gizzi et al.
Food additives and contaminants, 24(11), 1226-1235 (2007-09-14)
The performance characteristics of an analytical method based on high-performance liquid chromatography (HPLC) for the detection of the banned growth promoters, carbadox and olaquindox, in feedstuff were determined via a collaborative study. The relative standard deviation of repeatability (RSDr) ranged
L Beutin et al.
Antimicrobial agents and chemotherapy, 20(3), 336-343 (1981-09-01)
The quinoxaline-di-N-oxides carbadox, olaquindox, and quindoxin, which are potent antibacterial agents, were tested for mutagenicity in the Salmonella microsomal system. They all induced base pair substitutions and frameshift mutations in Salmonella, and occurred independently of the presence of a rat
Awais Ihsan et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 51, 330-336 (2012-10-16)
Quinoxaline-1,4-dioxides (QdNOs) are the potent heterocyclic N-oxides with interesting biological properties such as antibacterial, anticandida, antitubercular, anticancer and antiprotozoal activities. Here, we tested and compared the mequindox (MEQ) for mutagenic abilities in a battery of different short term tests according
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C6770-25G | 04061833511572 |