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Merck
CN

D029

R(−)-2,10,11-Trihydroxyaporphine hydrobromide

>97%, small crystals

Synonym(s):

R(−)-2-Hydroxyapomorphine hydrobromide

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About This Item

Empirical Formula (Hill Notation):
C17H17NO3 · HBr
CAS Number:
77630-01-4
Molecular Weight:
364.23
UNSPSC Code:
12352200
PubChem Substance ID:
24277902
MDL number:
MFCD00069240

Key Documents

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assay

>97%

form

small crystals

optical activity

[α]21/546 −103.6°, c = 0.4 in methanol(lit.)

color

gray to green

solubility

H2O: moderately soluble (dissolve in oxygen-free boiled water containing 0.1% sodium metabisulfite or other antioxidants.), dilute aqueous acid: moderately soluble, ethanol: moderately soluble, methanol: soluble

storage temp.

2-8°C

SMILES string

Br[H].[H][C@]12Cc3ccc(O)c(O)c3-c4cc(O)cc(CCN1C)c24

Gene Information

human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

Biochem/physiol Actions

Dopamine receptor agonist.

Disclaimer

Photosensitive and hygroscopic

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
091K4610
061K4608

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J L Neumeyer et al.
Journal of medicinal chemistry, 25(8), 990-992 (1982-08-01)
The enantiomers (6aR and 6aS) of 2,10,11-trihydroxyaporphine (THA) were synthesized from thebaine and bulbocapnine and evaluated pharmacologically in vitro in comparison with (-)-apomorphine [(-)-APO] and dopamine by competition with tritiated apomorphine, ADTN, and spiroperidol for binding to a membrane fraction
A E Lamers et al.
The American journal of physiology, 273(1 Pt 2), R387-R392 (1997-07-01)
A 7-day exposure of tilapia (Oreochromis mossambicus) to water with a pH of 4.5 activates their pituitary melanophore-stimulating hormone (MSH) cells to preferentially release diacetyl alpha-MSH as an important corticotrope (13). We here focus on the control of alpha-MSH release

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