D1634
Diosgenin
≥93%, apoptosis inducer, powder
Synonym(s):
(25R)-5-Spirosten-3β-ol, 3β-Hydroxy-5-spirostene, Nitogenin
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About This Item
Empirical Formula (Hill Notation):
C27H42O3
CAS Number:
Molecular Weight:
414.62
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
208-134-3
MDL number:
Beilstein/REAXYS Number:
94582
Product Name
Diosgenin, ≥93%
Quality Level
assay
≥93%
form
powder
SMILES string
[H][C@]12C[C@@]3([H])[C@]4([H])CC=C5C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@@]6(CC[C@@H](C)CO6)O2
InChI
1S/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3/t16-,17+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1
InChI key
WQLVFSAGQJTQCK-VKROHFNGSA-N
Gene Information
human ... UGT1A4(54657)
General description
Diosgenin is a triterpene and a glycone derivative of dioscin. Yams, Trigonella foenum-graecum and Costus speciosus are some of its source.
Application
Diosgenin has been:
- used as a standard in the analysis of total saponins in Sapindus rarak
- orally administered to the rats to study its role against atherogenic diet-induced production of inflammatory mediators in heart, liver and brain
- used as a standard compound to determine the saponins content in chickpea and Tribulus terrestris
Biochem/physiol Actions
Diosgenin induces apoptosis in colon cancer cell lines and induces apoptosis, cell cycle arrest and cyclooxygenase activity in osteosarcoma cells. It serves as a precursor in steroid drug production. Diosgenin is shown to promote cholesterol production by stimulating biliary excretion. It influences lipoxygenase induced human erythroleukemia cell line differentiation.
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Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Chung-Hsiung Huang et al.
Journal of natural products, 73(6), 1033-1037 (2010-05-15)
It was hypothesized that the suppressive effect of diosgenin (1) on the intestinal T helper (Th)2 responses is associated with an enhancement of the regulatory T-cell immunity. Ovalbumin (OVA)-sensitized BALB/c mice were gavaged daily with 1 and received repeatedly oral
Chung-Hsiung Huang et al.
International immunopharmacology, 42, 59-66 (2016-11-26)
Although the development of T helper (Th)1-like regulatory T (Treg) cells under Th1 inflammatory conditions has been reported, the role of Th1-like Treg cells in Th2 allergic responses remains mostly unclear. We previously demonstrated that diosgenin, the major sapogenin contained
Extraction of tannins and saponins from plant sources and their effects on in vitro methanogenesis and rumen fermentation
Yuliana P, et al.
Journal of the Indonesian Tropical Animal Agriculture, 39(2), 91-97 (2014)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D1634-100G | 04061833560334 |
| D1634-5G | 04061835556458 |