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D5038

2′-Deoxyguanosine 5′-triphosphate trisodium salt solution

100 mM (pH 7)

Synonym(s):

dGTP-Na3

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About This Item

Empirical Formula (Hill Notation):
C10H13N5Na3O13P3
CAS Number:
93919-41-6
Molecular Weight:
573.13
NACRES:
NA.52
PubChem Substance ID:
24893919
UNSPSC Code:
41106305
EC Number:
300-026-5
MDL number:
MFCD00080337
Assay:
≥99%
Form:
liquid
Storage temp.:
−20°C

Key Documents

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assay

≥99%

Quality Level

200

form

liquid

concentration

100 mM (pH 7)

color

colorless

foreign activity

DNase, RNase, none detected

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Na+].[Na+].[Na+].NC1=Nc2c(ncn2[C@H]3C[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)O3)C(=O)N1

InChI

1S/C10H16N5O13P3.3Na/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17);;;/q;3*+1/p-3/t4-,5+,6+;;;/m0.../s1

InChI key

IWGGLKOTEOCWQP-BIHLCPNHSA-K

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General description

2′-Deoxyguanosine 5′-triphosphate (dGTP) is made of a guanine nucleobase attached to deoxyribose and a 5′-hydroxyl on the sugar linked to a chain of three phosphate residues. It is used by the cells for the synthesis of DNA with the help of DNA polymerase.

Application

2′-Deoxyguanosine 5′-triphosphate trisodium salt solution has been used:

  • in a reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification.
  • as a component of the PCR mix for in situ reverse transcription-polymerase chain reaction (RT-PCR) amplification of mRNA from prokaryotic and eukaryotic ribosomes
  • to study the mutations in the HBB gene via amplification refractory mutation system (ARMS)-PCR
2′-Deoxyguanosine 5′-triphosphate trisodium salt is utilized for methods such as DNA sequencing, PCR and other DNA polymerase based DNA synthesis and repair techniques.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF8733V
WXBF1050V
WXBF8644V
0000381282
0000381282

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Functional Protein Microarrays in Drug Discovery (2008)
Alex von Kriegsheim et al.
Methods in molecular biology (Clifton, N.J.), 484, 177-192 (2008-07-02)
Signaling pathways transduce extracellular stimuli from the membrane to the nucleus. Constitutive and thus inappropriate stimulation of these kinase cascades is associated with and observed in a majority of tumors. The transduction of signals in these pathways is achieved through
Analysis of beta globin gene mutations in Diyarbakir
Tekecs S, et al.
Turkish Journal of Biology (2021)
Marco Gatti et al.
Cell reports, 32(5), 107985-107985 (2020-08-07)
PARP inhibitors (PARPi) cause synthetic lethality in BRCA-deficient tumors. Whether specific vulnerabilities to PARPi exist beyond BRCA mutations and related defects in homology-directed repair (HDR) is not well understood. Here, we identify the ubiquitin E3 ligase TRIP12 as negative regulator

Global Trade Item Number

SKUGTIN
D5038-.1MMO04061833451038
D5038-25UMO04061833697030

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