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Merck
CN

D6038

Desoximetasone

Synonym(s):

9-Fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione

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About This Item

Empirical Formula (Hill Notation):
C22H29FO4
CAS Number:
382-67-2
Molecular Weight:
376.46
UNSPSC Code:
41116107
PubChem Substance ID:
24893994
EC Number:
206-845-3
MDL number:
MFCD00083301

Key Documents

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technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

format

neat

SMILES string

[H][C@@]12C[C@@H](C)[C@H](C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1

InChI key

VWVSBHGCDBMOOT-IIEHVVJPSA-N

Gene Information

human ... NR3C1(2908)

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
090M1300
096K1526
025K1047
101K1204
020K1603

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Allergic contact dermatitis from dioctyl sodium sulfosuccinate in a topical corticosteroid.
A Y Lee et al.
Contact dermatitis, 38(6), 355-356 (1998-08-01)
Valery Serbezov
Recent patents on nanotechnology, 7(1), 26-40 (2012-07-04)
The applications of Pulsed Laser Deposition (PLD) for producing nanoparticles, nanostructures and nanocomposites coatings based on recently developed laser ablating techniques and their convergence are being reviewed. The problems of in situ synthesis of hybrid inorganic-organic nanocomposites coatings by these
C Borelli et al.
Skin pharmacology and physiology, 21(3), 181-187 (2008-06-05)
We report on a double-blind, vehicle-controlled, single-center confirmatory study with random assignment. The purpose of the study was to investigate the topical bioavailability of different topical corticosteroid formulations in healthy human beings focussing on desoximetasone (DM). Two DM 0.25% formulations
B Przybilla et al.
Zeitschrift fur Hautkrankheiten, 63(1), 60-62 (1988-01-18)
In a comparative study, 20 ambulatory patients suffering from chronic psoriasis vulgaris with plaques were treated with preparations containing either dithranol (0.1/0.2%) plus urea (17%) or desoximetasone (0.25%). In the two groups, 7 and 8 courses, resp., could be evaluated.
L H Kligman
Acta dermato-venereologica, 74(1), 18-19 (1994-01-01)
The hairless mouse model of a UVA-induced dermal neutrophilic infiltrate was used to compare the efficacy of equal concentrations of name brand versus generic corticosteroids. The generic brand was significantly less effective in suppressing the inflammatory response.
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