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Merck
CN

D6038

Desoximetasone

Synonym(s):

9-Fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione

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About This Item

Empirical Formula (Hill Notation):
C22H29FO4
CAS Number:
382-67-2
Molecular Weight:
376.46
UNSPSC Code:
41116107
PubChem Substance ID:
24893994
EC Number:
206-845-3
MDL number:
MFCD00083301

Key Documents

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InChI key

VWVSBHGCDBMOOT-IIEHVVJPSA-N

InChI

1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1

SMILES string

[H][C@@]12C[C@@H](C)[C@H](C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

format

neat

Gene Information

human ... NR3C1(2908)

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
090M1300
096K1526
025K1047
101K1204
020K1603

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Parinbhai Shah et al.
Pharmaceutics, 12(3) (2020-03-19)
Topical corticosteroids are used to treat a variety of skin conditions such as allergic reactions, eczema, and psoriasis. Niosomes are a novel surfactant-based delivery system that may be used to deliver desoximetasone via topical product application in order to mitigate
Morbilliform erythema-multiforme-like eruption from desoxymethasone.
L Stingeni et al.
Contact dermatitis, 35(6), 363-364 (1996-12-01)
Premjit Juntongjin et al.
Dermatologic therapy, 32(4), e12956-e12956 (2019-05-10)
Topical potent corticosteroids are the mainstay of treatment for chronic hand eczema (CHE). However, there are numerous adverse effects associated with the chronic use of topical corticosteroids. Calcipotriol has been widely used in psoriasis and has been reported to achieve
Photosensitivity to desoximetasone emollient cream.
M B Stierstorfer et al.
Archives of dermatology, 124(12), 1870-1871 (1988-12-01)
Allergic reactions to topical desoxymethasone and oral triamcinolone.
L Brambilla et al.
Contact dermatitis, 21(4), 272-274 (1989-10-01)
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