D6321
Droxinostat
≥98% (HPLC)
Synonym(s):
4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide
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About This Item
Empirical Formula (Hill Notation):
C11H14ClNO3
CAS Number:
Molecular Weight:
243.69
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: ≥20 mg/mL
storage temp.
2-8°C
SMILES string
Cc1cc(Cl)ccc1OCCCC(=O)NO
InChI
1S/C11H14ClNO3/c1-8-7-9(12)4-5-10(8)16-6-2-3-11(14)13-15/h4-5,7,15H,2-3,6H2,1H3,(H,13,14)
InChI key
JHSXDAWGLCZYSM-UHFFFAOYSA-N
Biochem/physiol Actions
Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Ying Huang et al.
Cellular & molecular biology letters, 23, 34-34 (2018-08-02)
Upregulation of histone acetylation plays a critical role in the dysregulation of transcription. It alters the structure of chromatin, which leads to the onset of cancer. Histone deacetylase inhibitors may therefore be a promising way to limit cancer progression. In
Histone Deacetylase 3 Inhibition Overcomes
Azusa Tanimoto et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(12), 3139-3149 (2016-12-18)
Gera Goverse et al.
Journal of immunology (Baltimore, Md. : 1950), 198(5), 2172-2181 (2017-01-20)
The gastrointestinal tract is continuously exposed to many environmental factors that influence intestinal epithelial cells and the underlying mucosal immune system. In this article, we demonstrate that dietary fiber and short chain fatty acids (SCFAs) induced the expression of the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D6321-25MG | 04061832270395 |
| D6321-5MG | 04061832644936 |