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D6665

2′,7′-Dichlorofluorescein

Name: 2&#8242;,7&#8242;-Dichlorofluorescein
Brand: SIGMA

~90% purity (TLC) (85- 100% purity), powder

Synonym(s):

Dichlorofluorescein; Fluorescein 27

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₁₀Cl₂O₅

CAS Number:

76-54-0

Molecular Weight:

401.20

NACRES:

NA.47

PubChem Substance ID:

24894041

UNSPSC Code:

12171500

EC Number:

200-968-6

MDL number:

MFCD00005047

Beilstein/REAXYS Number:

58009

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Properties

Product Name

2′,7′-Dichlorofluorescein, suitable for use as an indicator in chloride titration, ~90% (TLC), powder

Quality Level

200

assay

~90% (TLC)

form

powder

technique(s)

titration: suitable

mp

280 °C (dec.) (lit.)

solubility

ethanol: 25 mg/mL

density

0.79 g/cm³

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

Oc1cc2Oc3cc(O)c(Cl)cc3C4(OC(=O)c5ccccc45)c2cc1Cl

InChI

1S/C20H10Cl2O5/c21-13-5-11-17(7-15(13)23)26-18-8-16(24)14(22)6-12(18)20(11)10-4-2-1-3-9(10)19(25)27-20/h1-8,23-24H

InChI key

VFNKZQNIXUFLBC-UHFFFAOYSA-N

Description

General description

2′,7′-Dichlorofluorescein is an oxidation-sensitive fluorescent probe. 2′7′-dichlorofluorescein diacetate is oxidized to 2′7′-dichlorofluorescein in the presence of ROS (reactive oxygen species).citation

Application

2′,7′-Dichlorofluorescein has been used as an oxidation-sensitive fluorescent probe to measure ROS (reactive oxygen species) formation in cells.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Cysteamine suppresses human peripheral blood mononuclear cells--human corneal endothelial cell reaction via reactive oxygen species reduction.

Shin YJ, et al.

Molecular Vision, 17, 3371-3378 (2011)

Chloride secretion induced by rotavirus is oxidative stress-dependent and inhibited by Saccharomyces boulardii in human enterocytes.

Vittoria Buccigrossi et al.

PloS one, 9(6), e99830-e99830 (2014-06-12)

Rotavirus (RV) infection causes watery diarrhea via multiple mechanisms, primarily chloride secretion in intestinal epithelial cell. The chloride secretion largely depends on non-structural protein 4 (NSP4) enterotoxic activity in human enterocytes through mechanisms that have not been defined. Redox imbalance

Homocysteine induces oxidative-nitrative stress in heart of rats: prevention by folic acid.

Janaína Kolling et al.

Cardiovascular toxicology, 11(1), 67-73 (2010-11-16)

Hyperhomocysteinemia is a risk factor for cardiovascular disease, stroke, and thrombosis; however, the mechanisms by which homocysteine triggers these dysfunctions are not fully understood. In the present study, we investigated the effect of chronic hyperhomocysteinemia on some parameters of oxidative

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Global Trade Item Number

SKU	GTIN
D6665-25G	04061833587812
D6665-5G	04061835347520