D7032
3,5-Diiodothyropropionic acid
≥98% (HPLC)
Synonym(s):
DITPA
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About This Item
Empirical Formula (Hill Notation):
C15H12I2O4
CAS Number:
Molecular Weight:
510.06
UNSPSC Code:
12352200
MDL number:
assay
≥98% (HPLC)
storage temp.
2-8°C
SMILES string
OC(=O)CCc1cc(I)c(Oc2ccc(O)cc2)c(I)c1
Biochem/physiol Actions
DITPA, an analog of L-thyroxine, has inotropic but not chronotropic effects on heart muscle. It also stimulates myocardial angiogenesis after infarction by interaction with integrin αvཪ3 at the cell surface.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Saurin Raval
Expert opinion on therapeutic patents, 20(4), 593-596 (2010-03-03)
The patent application WO2008106213 describes the beneficial effects of thyroid hormone analogue 3,5 diiodothyropropionic acid (DITPA) such as stimulating weight loss in overweight mammals, lowering of triglyceride and treating metabolic syndrome in humans. The human population of the patients selected
Yingheng Liu et al.
American journal of physiology. Heart and circulatory physiology, 296(5), H1551-H1557 (2009-03-17)
Patients with hypothyroidism are at a higher risk for coronary vascular disease. Patients with diabetes and related vascular complications also have an increased incidence of low thyroid function. While thyroid hormones (THs) may be key regulators of a healthy vasculature
Peter H Spooner et al.
Journal of cardiovascular pharmacology, 44(4), 453-459 (2004-09-30)
This study was designed to determine if the thyroid hormone analog 3,5 diiodothyropropionic acid (DITPA), now in clinical trials for heart failure, alters endothelial function after myocardial infarction (MI). Three weeks after MI, adult Sprague-Dawley rats were randomly assigned to